دورية أكاديمية
Coexpression of TLR9 and VEGF-C is associated with lymphatic metastasis in prostate cancer
| العنوان: | Coexpression of TLR9 and VEGF-C is associated with lymphatic metastasis in prostate cancer |
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| المؤلفون: | Xian-Zi Zeng, Zhan-Sen Huang, Hong-Peng Fang, Jie-Ying Wu, Qun-Xiong Huang, Chu-Bin Zhuang, Jing Zhou, Jin-Ming Di |
| المصدر: | Asian Journal of Andrology, Vol 24, Iss 4, Pp 380-385 (2022) |
| بيانات النشر: | Wolters Kluwer Medknow Publications, 2022. |
| سنة النشر: | 2022 |
| المجموعة: | LCC:Diseases of the genitourinary system. Urology |
| مصطلحات موضوعية: | biochemical progression-free survival, coexpression, lymphatic metastasis, prostate cancer, toll-like receptor 9, vascular endothelial growth factor c, Diseases of the genitourinary system. Urology, RC870-923 |
| الوصف: | Prostate cancer (PCa) is one of the most frequent cancers in men, and its biomolecular targets have been extensively studied. This study aimed to analyze the expression of toll-like receptor 9 (TLR9) and vascular endothelial growth factor C (VEGF-C) and the clinical value of the coexpression of TLR9 and VEGF-C in PCa. We retrospectively evaluated 55 patients with clinically localized, intermediate-risk, or high-risk PCa who underwent laparoscopic radical prostatectomy (LRP) and extended pelvic lymph node dissection (ePLND) without neoadjuvant hormonal therapy at a single institution from June 2013 to December 2016. In all 55 patients, the median number of lymph nodes (LNs) resected was 23 (range: 18–31), and a total of 1269 LNs were removed, of which 78 LNs were positive. Seventeen patients had positive LNs, with a positive rate of 30.9%. In addition, the immunohistochemical results in the above patients revealed that high TLR9 expression was correlated with higher Gleason score (GS) (P = 0.049), increased LN metastasis (P = 0.004), and more perineural invasion (PNI) (P = 0.033). Moreover, VEGF-C expression was associated with GS (P = 0.040), pathological stage (pT stage) (P = 0.022), LN metastasis (P = 0.003), and PNI (P = 0.001). Furthermore, a significant positive correlation between TLR9 and VEGF-C was found (P < 0.001), and the TLR9/VEGF-C phenotype was associated with LN metastasis (P = 0.047). Collectively, we propose that TLR9 stimulation may promote LN metastasis in PCa cells through the upregulation of VEGF-C expression, thereby affecting the prognosis of PCa patients. Therefore, these markers may serve as valuable targets for the treatment of PCa. |
| نوع الوثيقة: | article |
| وصف الملف: | electronic resource |
| اللغة: | English |
| تدمد: | 1008-682X 1745-7262 |
| العلاقة: | http://www.ajandrology.com/article.asp?issn=1008-682X;year=2022;volume=24;issue=4;spage=380;epage=385;aulastTest=; https://doaj.org/toc/1008-682XTest; https://doaj.org/toc/1745-7262Test |
| DOI: | 10.4103/aja202167 |
| الوصول الحر: | https://doaj.org/article/daaa62df21dc482b81f7f36c4342f2c3Test |
| رقم الانضمام: | edsdoj.62df21dc482b81f7f36c4342f2c3 |
| قاعدة البيانات: | Directory of Open Access Journals |
Full Text Finder | تدمد: | 1008682X 17457262 |
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| DOI: | 10.4103/aja202167 |