دورية أكاديمية
Diagnosing external ventricular drain-related ventriculitis by means of local inflammatory response: soluble triggering receptor expressed on myeloid cells-1.
| العنوان: | Diagnosing external ventricular drain-related ventriculitis by means of local inflammatory response: soluble triggering receptor expressed on myeloid cells-1. |
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| المؤلفون: | Gordón Sahuquillo, Mónica, Ramírez Galleymore, Paula, Soriano Viladomiu, Alex, Palomo, Manuel, López Ferraz, Cristina, Villarreal, Esther, Meseguer, Salome, Gomez, Maria Dolores, Folgado, Carlos, Bonastre, Juan |
| المصدر: | Articles publicats en revistes (Medicina) |
| بيانات النشر: | BioMed Central |
| سنة النشر: | 2014 |
| المجموعة: | Dipòsit Digital de la Universitat de Barcelona |
| مصطلحات موضوعية: | Malalties del sistema nerviós central, Glicoproteïnes, Immunologia, Central nervous system diseases, Glycoproteins, Immunology |
| الوصف: | INTRODUCTION: External ventricular drainage (EVD)-related ventriculitis is one of the most severe complications associated with the use of EVDs. Establishing an early and certain diagnosis can be difficult in critically ill patients. We performed this prospective study to evaluate the usefulness of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) determination in cerebrospinal fluid (CSF) in the diagnosis of ventriculitis. METHODS: A prospective observational study was conducted of 73 consecutive patients with EVD. Samples of CSF for culture, cytobiochemical analysis and sTREM-1 determination were extracted three times a week. Ventriculitis diagnosis required a combination of microbiological, cytobiochemical and clinical criteria. RESULTS: Seventy-three consecutive patients were included. EVD-related ventriculitis was diagnosed in six patients and EVD-colonization in ten patients. Patients without clinical or microbiological findings were considered controls. The median CSF sTREM-1 was 4,320 pg/ml (interquartile range (IQR): 2,987 to 4,886) versus 266 pg/ml (118 to 689); P <0.001. There were no differences when comparing colonized-patients and controls. The best cut-off sTREM-1 value for the diagnosis of ventriculitis was 2,388.79 pg/ml (sensitivity 100%, specificity 98.5%, positive predictive value 85.71%, negative predictive value 100%). CSF proteins, glucose and the ratio CSF/serum glucose were also significantly different (P = 0.001). Serum biomarkers were not useful to diagnose EVD-related infection. These results were confirmed by a case-control study with ventriculitis patients (cases) and non-ventriculitis (control subjects) matched by age, comorbidities, severity scales and EVD duration (P = 0.004). CONCLUSIONS: CSF sTREM-1 was useful in the diagnosis of ventriculitis, in a similar measure to classical CSF parameters. Furthermore, CSF sTREM-1 could prove the diagnosis in uncertain cases and discriminate between EVD-colonization and infection |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 8 p.; application/pdf |
| اللغة: | English |
| تدمد: | 1364-8535 |
| العلاقة: | Reproducció del document publicat a: https://doi.org/10.1186/s13054-014-0567-0Test; Critical Care, 2014, vol. 18, num. 5, p. 567; https://doi.org/10.1186/s13054-014-0567-0Test; http://hdl.handle.net/2445/109684Test; 668545 |
| الإتاحة: | https://doi.org/10.1186/s13054-014-0567-0Test http://hdl.handle.net/2445/109684Test |
| حقوق: | cc-by (c) Gordón Sahuquillo, Mónica et al., 2014 ; http://creativecommons.org/licenses/by/3.0/esTest ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.4862A9EE |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 13648535 |
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