دورية أكاديمية
A simple score to predict early severe infections in patients with newly diagnosed multiple myeloma
| العنوان: | A simple score to predict early severe infections in patients with newly diagnosed multiple myeloma |
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| المؤلفون: | Encinas, Cristina, Hernandez Rivas, José Ángel, Oriol, Albert, Rosiñol, Laura, Blanchard, María Jesús, Bellón, José María, García Sanz, Ramón, Rubia, Javier de la, López de la Guía, Ana, Jímenez Ubieto, Ana, Jarque, Isidro, Iñigo, Belén, Dourdil, Victoria, Arriba, Felipe de, Cuéllar Pérez-Ávila, Clara, Gonzalez, Yolanda, Hernández, Miguel Teodoro, Bargay, Joan, Granell, Miguel, Rodríguez Otero, Paula, Silvent, Maialen, Cabrera, Carmen, Rios, Rafael, Alegre, Adrián, Gironella, Mercedes, Gonzalez, Marta Sonia, Sureda, Anna, Sampol, Antonia, Ocio, Enrique M., Krsnik, Isabel, García, Antonio, García Mateo, Aránzazu, Soler, Joan Alfons, Martín, Jesús, Arguiñano Pérez, José Mª, Mateos, María Victoria, Bladé, J. (Joan), San Miguel, Jesús F., Lahuerta, Juan José, Martínez López, Joaquín, Gem/pethema (Grupo Español de Mieloma/Programa para el estudio de la terapéutica en hemopatías malignas) Cooperative Study Group |
| المصدر: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
| بيانات النشر: | Springer Science and Business Media LLC |
| سنة النشر: | 2022 |
| المجموعة: | Dipòsit Digital de la Universitat de Barcelona |
| مصطلحات موضوعية: | Mieloma múltiple, Antibiòtics, Multiple myeloma, Antibiotics |
| الوصف: | Infections remain a common complication in patients with multiple myeloma (MM) and are associated with morbidity and mortality. A risk score to predict the probability of early severe infection could help to identify the patients that would benefit from preventive measures. We undertook a post hoc analysis of infections in four clinical trials from the Spanish Myeloma Group, involving a total of 1347 patients (847 transplant candidates). Regarding the GEM2010 > 65 trial, antibiotic prophylaxis was mandatory, so we excluded it from the final analysis. The incidence of severe infection episodes within the first 6 months was 13.8%, and majority of the patients experiencing the first episode before 4 months (11.1%). 1.2% of patients died because of infections within the first 6 months (1% before 4 months). Variables associated with increased risk of severe infection in the first 4 months included serum albumin <= 30 g/L, ECOG > 1, male sex, and non-IgA type MM. A simple risk score with these variables facilitated the identification of three risk groups with different probabilities of severe infection within the first 4 months: low-risk (score 0-2) 8.2%; intermediate-risk (score 3) 19.2%; and high-risk (score 4) 28.3%. Patients with intermediate/high risk could be candidates for prophylactic antibiotic therapies. |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 8 p.; application/pdf |
| اللغة: | English |
| تدمد: | 2044-5385 |
| العلاقة: | Reproducció del document publicat a: https://doi.org/10.1038/s41408-022-00652-2Test; Blood Cancer Journal, 2022, vol. 12, num. 4; https://doi.org/10.1038/s41408-022-00652-2Test; http://hdl.handle.net/2445/185581Test |
| الإتاحة: | https://doi.org/10.1038/s41408-022-00652-2Test http://hdl.handle.net/2445/185581Test |
| حقوق: | cc by (c) Encinas, Cristina et al, 2022 ; http://creativecommons.org/licenses/by/3.0/esTest/ ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.40E81741 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20445385 |
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