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The metastasis promoting protein S100A4 levels associate with disease activity rather than cancer development in patients with idiopathic inflammatory myopathies

التفاصيل البيبلوغرافية
العنوان: The metastasis promoting protein S100A4 levels associate with disease activity rather than cancer development in patients with idiopathic inflammatory myopathies
المؤلفون: L. Pleštilová, Jiří Vencovský, Ladislav Šenolt, Ondřej Pecha, Lucie Andrés Cerezo, Heřman Mann
المصدر: Arthritis Research & Therapy
بيانات النشر: Springer Nature
مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Immunology, Enzyme-Linked Immunosorbent Assay, Severity of Illness Index, Gastroenterology, Polymyositis, Dermatomyositis, Metastasis, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Rheumatology, Neoplasms, Lactate dehydrogenase, Internal medicine, medicine, Humans, Immunology and Allergy, S100 Calcium-Binding Protein A4, Creatine Kinase, Myositis, Aged, Autoantibodies, 030304 developmental biology, 030203 arthritis & rheumatology, 0303 health sciences, L-Lactate Dehydrogenase, biology, business.industry, S100 Proteins, C-reactive protein, Cancer, Middle Aged, medicine.disease, 3. Good health, C-Reactive Protein, chemistry, biology.protein, Female, Creatine kinase, business, Biomarkers, Research Article
الوصف: Introduction The aim was to evaluate S100A4 protein as a biomarker of disease activity and potential cancer development in patients with myositis. Methods Serum levels of S100A4 were determined in 43 dermatomyositis (DM), 39 polymyositis (PM) and 22 cancer associated myositis (CAM) patients as well as in 77 healthy controls. The associations between S100A4 levels, inflammation, disease activity, muscle strength and cancer development were evaluated. Results All myositis patients had significantly higher serum levels of S100A4 protein compared to healthy controls (median (IQR): 31.5 (17.4 to 59.5) versus 23.8 (14.5 to 33.7) ng/ml, P
اللغة: English
تدمد: 1478-6354
DOI: 10.1186/s13075-014-0468-2
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d713e5278e8eb145244c78ae38762632Test
حقوق: OPEN
رقم الانضمام: edsair.doi.dedup.....d713e5278e8eb145244c78ae38762632
قاعدة البيانات: OpenAIRE
الوصف
تدمد:14786354
DOI:10.1186/s13075-014-0468-2