التفاصيل البيبلوغرافية
| العنوان: |
Effects of misoprostrol on pentylenetetrazol-induced seizures in mice |
| المؤلفون: |
Medeiros,Francisco das Chagas, Medeiros,Maria Angelina, Rao,Vietla Satyanarayna, Figueiredo,Eberval Gadelha |
| المصدر: |
Arquivos de Neuro-Psiquiatria v.55 n.4 1997 |
| بيانات النشر: |
Academia Brasileira de Neurologia - ABNEURO |
| سنة النشر: |
1997 |
| المجموعة: |
SciELO Brazil (Scientific Electronic Library Online) |
| مصطلحات موضوعية: |
seizures, pentylenetetrazol, misoprostol, mice |
| الوصف: |
The effects of prostaglandin E - analogue misoprostol on the susceptibility to pentilenetetrazol(PTZ) - induced seizures were examined in mice. Misoprostol (200-800 mg/kg), given subcutaneously 45 min before the subconvulsive dose of PTZ (30 mg/kg, i.p) provoked dose-dependent clonic-tonic seizures (30 to 100%) and mortality in mice. At 300 g/kg, s.c, misoprostol pretreatment significantly (p<0.05) lowered the onset latency to first convulsion as well as the latency to mortality induced by a convulsive dose of PTZ (60 mg/kg, i.p.). At this dose misoprostol was found to lower the CD50 and Ld50 values for PTZ by 21 % and 36% respectively. The results suggest that prostaglandins are likely to lower the threshold for convulsions. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
text/html |
| اللغة: |
English |
| الإتاحة: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X1997000500001Test |
| رقم الانضمام: |
edsbas.995F55C6 |
| قاعدة البيانات: |
BASE |
