التفاصيل البيبلوغرافية
| العنوان: |
EVALUATION OF HUMAN LEUKOCYTE ANTIGEN CLASS I AND II ANTIGENS IN HELICOBACTER PYLORI-POSITIVE PEDIATRIC PATIENTS WITH ACTIVE GASTRITIS AND DUODENAL ULCER |
| المؤلفون: |
GÖNEN,Sevim, SARI,Sinan, KANDUR,Yaşar, DALGIÇ,Buket, SÖYLEMEZOĞLU,Oğuz |
| المصدر: |
Arquivos de Gastroenterologia v.54 n.4 2017 |
| بيانات النشر: |
Instituto Brasileiro de Estudos e Pesquisas de Gastroenterologia - IBEPEGE; Colégio Brasileiro de Cirurgia Digestiva - CBCD; Sociedade Brasileira de Motilidade Digestiva e Neurogastroenterologia - SBMDN; Federação Brasileira de Gastroenterologia - FBG; Sociedade Brasileira de Hepatologia - SBH; Sociedade Brasileira de Endoscopia Digestiva - SOBED |
| سنة النشر: |
2017 |
| المجموعة: |
SciELO Brazil (Scientific Electronic Library Online) |
| مصطلحات موضوعية: |
Duodenal ulcer, Gastritis, Helicobacter pylori, HLA Antigens, Child |
| الوصف: |
BACKGROUND: As being the first bacteria determined to be carcinogenic, Helicobacter pylori (H. pylori) is a pathogen localized in the stomach in more than half of the world population. Some earlier studies have found a relation between tissue histocompatibility antigens and gastric cancers depending on the regions. OBJECTIVE: The present study aimed to determine the distribution of human leukocyte antigen (HLA) class I and class II antigens in H. pylori-positive pediatric patients with active gastritis and duodenal ulcer, excluding cancer cases, in our center. METHODS: The study included 40 patients diagnosed with H. pylori-positive active gastritis and duodenal ulcer and 100 controls consisting of healthy donor candidates. The HLA class I and class II antigens were studied in the isolated DNA samples using the polymerase chain reaction sequence-specific oligonucleotide probes. RESULTS: The frequency of HLA-B*51 antigen was significantly higher in the patient group than in the control group (40% vs 17%; P=0.003). There was no difference between the two groups in terms of the frequencies of HLA-A, HLA-C, HLA-DR, and HLA-DQ antigens. CONCLUSION: It was determined that HLA-B*51 plays a critical role in H. pylori infection. |
| نوع الوثيقة: |
article in journal/newspaper |
| وصف الملف: |
text/html |
| اللغة: |
English |
| الإتاحة: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-28032017000400297Test |
| حقوق: |
info:eu-repo/semantics/openAccess |
| رقم الانضمام: |
edsbas.98E5FE3E |
| قاعدة البيانات: |
BASE |
