Lower BAFF Levels in Myasthenic Patients Treated with Glucocorticoids
| العنوان: | Lower BAFF Levels in Myasthenic Patients Treated with Glucocorticoids |
|---|---|
| المؤلفون: | Beata Szyluk, Marta Lipowska, Piotr Szczudlik, Ewa Sobieszczuk, Anna Kostera-Pruszczyk, Małgorzata Dutkiewicz, Justyna Kubiszewska |
| المصدر: | Archivum Immunologiae et Therapiae Experimentalis |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Adolescent, medicine.medical_treatment, Immunology, Gastroenterology, Young Adult, Internal medicine, Myasthenia Gravis, medicine, Humans, Immunology and Allergy, In patient, B-cell activating factor, Glucocorticoids, Cytokine, Aged, Aged, 80 and over, Adult patients, biology, business.industry, MG, Thymus Neoplasms, General Medicine, Middle Aged, medicine.disease, Myasthenia gravis, Thymectomy, Cross-Sectional Studies, biology.protein, BAFF, Original Article, Female, Tumor necrosis factor alpha, Antibody, business |
| الوصف: | B-cell activating factor (BAFF), a member of tumor necrosis factor family, activates B cells, promotes their survival and proliferation. BAFF is considered to have an influence on development of autoimmune diseases including myasthenia gravis (MG). We aimed to evaluate BAFF serum levels in MG patients, their potential connection with therapy and course of MG. Cross-sectional study. Two hundred eighteen adult patients with MG (67% women, age: 18–89 years, 82.6% AChR antibody seropositive (AChRAb(+)). Serum BAFF levels, their relationship with severity of clinical symptoms, therapy conducted, clinical and demographic features and other factors were analyzed. Patients with AChRAb(+) MG demonstrated significantly higher BAFF levels than MuSK-MG patients (831.2 ± 285.4 pg/ml vs. 745.6 ± 633.4 pg/ml, respectively; p = 0.030). Serum BAFF levels in women were significantly higher than in men (855.9 ± 302.5 vs. 756.6 ± 289.4, respectively; p = 0.017). Mean serum BAFF level was significantly decreased in patients who were ever treated with corticosteroids (CS) (770.4 ± 327.8 pg/ml vs. 891.3 ± 246.1 pg/ml, respectively; p = 0.001). Thymoma-MG patients demonstrated significantly lower BAFF levels (671.2 ± 244.9 vs. 833.5 ± 302.4, respectively; p = 0.044). Thymectomized patients did not differ in BAFF levels from the MG patients who had not undergone thymectomy. In multiple linear regression model, recent CS therapy and male sex were found to be independent predictors of lower BAFF levels. Serum BAFF level is decreased in patients treated with CS, which may suggest inhibiting influence of CS on BAFF—a potential mechanism contributing to the effectiveness of such therapy. |
| تدمد: | 1661-4917 0004-069X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77db3a00fb1f1d67723379a755049facTest https://doi.org/10.1007/s00005-021-00626-5Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....77db3a00fb1f1d67723379a755049fac |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16614917 0004069X |
|---|