التفاصيل البيبلوغرافية
| العنوان: |
The effectiveness of N-acetylcysteine in isolated hepatocytes, against the toxicity of paracetamol, acrolein, and paraquat. |
| المؤلفون: |
Dawson, Janet, Norbeck, Kajsa, Anundi, Irene, Moldéus, Peter |
| المصدر: |
Archives of Toxicology; Mar1984, Vol. 55 Issue 1, p11-15, 5p |
| مستخلص: |
The protective effect of N-acetylcysteine against the toxicity of paracetamol, acrolein, and paraquat was investigated using isolated hepatocytes as the experimental system. N-acetylcysteine protects against paracetamol toxicity by acting as a precursor for intracellular glutathione. N-acetylcysteine protects against acrolein toxicity by providing a source of sulfhydryl groups, and is effective without prior conversion. Paraquat toxicity can be decreased by coincubating the cells with N-acetylcysteine, but the mechanism for the protective effect is not as clear in this instance. It is probable that N-acetylcysteine protects against paraquat toxicity by helping to maintain intracellular glutathinone levels. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
