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1Detection of the mechanism of immunotoxicity of cyclosporine A in murine in vitro and in vivo models
المؤلفون: Mirjam M. Schaap, E. van Someren, Peter C. J. Schmeits, Peter J.M. Hendriksen, M. Luijten, Ad A. C. M. Peijnenburg, H. van Loveren, André Boorsma
المساهمون: Promovendi ODB, Gezondheidsvoorlichting, Toxicogenomics, GezondheidsRisico Analyse en Toxicologie, RS: GROW - Oncology, RS: GROW - R3 - Innovative Cancer Diagnostics & Therapy
المصدر: Archives of Toxicology, 12, 89, 2325-2337
Archives of Toxicology, 89(12), 2325-2337
Archives of Toxicology 89 (2015) 12
Archives of Toxicology, 89(12), 2325-2337. Springerمصطلحات موضوعية: Male, Interspecies comparison, Mouse, Novel Foods & Agrochains, Health, Toxicology and Mutagenesis, RAPID - Risk Analysis for Products in Development, C57BL/6, Biomedical Innovation, Toxicology, Novel Foods & Agroketens, Jurkat cells, Interleukin 2, Unfolded protein response, Jurkat Cells, Mice, In vivo study, Life, Cytotoxic T cell, Immunotoxicity, BU Toxicology, Novel Foods & Agrochains, Splenocytes, Messenger RNA, BU Toxicology, General Medicine, Hep G2 Cells, Cell cycle, Endoplasmic Reticulum Stress, Cell biology, Up-Regulation, CTLL-2, medicine.anatomical_structure, BU Toxicologie, Novel Foods & Agroketens, Cyclosporine, Endoplasmic reticulum stress, Animal cell, Healthy Living, Immunosuppressive Agents, medicine.drug, Human, Cell type, Thymoma, Dpleen cell, BU Toxicologie, T cell, Down-Regulation, Down regulation, Biology, T lymphocyte activation, Cell Line, Thymoma cell line, Transcription factor Nrf2, Cyclosporine A, In vivo, Cell Line, Tumor, Upregulation, medicine, Animals, Humans, Animal experiment, Immune response, Transcriptomics, Protein Unfolding, HepG2 cell line, Cytotoxic T lymphocyte, Gene Expression Profiling, In vitro study, Nonhuman, Jurkat cell line, Mice, Inbred C57BL, Human cell, Cell culture, ELSS - Earth, Life and Social Sciences, Cell cycle regulation, Controlled study, Spleen, T-Lymphocytes, Cytotoxic
وصف الملف: application/octet-stream; application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5be7ec6d1a47efd3d841c0af6f5ca0a4Test
https://doi.org/10.1007/s00204-014-1365-9Test -
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المؤلفون: Patrick Gourmelon, Elise Grignard, Jean-Marc A. Lobaccaro, Maamar Souidi, Stéphane Grison, Yann Gueguen
المساهمون: Radiobiologie et épidémiologie (DRPH/SRBE), Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Centre d'Enseignement et de Recherche en Nutrition Humaine d'Auvergne
المصدر: Archives of Toxicology
Archives of Toxicology, 2008, 82 (9), pp.583-589. ⟨10.1007/s00204-007-0268-4⟩مصطلحات موضوعية: Male, steroidogenesis, liver X receptor beta, liver X receptor alpha, [SDV]Life Sciences [q-bio], Health Status, Health, Toxicology and Mutagenesis, Messenger, Toxicology, 030218 nuclear medicine & medical imaging, Rats, Sprague-Dawley, chemistry.chemical_compound, contamination, 0302 clinical medicine, Corticosterone, Adrenal Glands, Testis, rat, chernobyl accident, 0303 health sciences, messenger RNA, Reverse Transcriptase Polymerase Chain Reaction, article, water contamination, General Medicine, 3. Good health, priority journal, Cesium Radioisotopes, cell nucleus receptor, Steroids, chemical modification, liver X receptor, corticosteroid, medicine.medical_specialty, animal experiment, Biology, animal tissue, long term exposure, electric power plant, in vivo study, 03 medical and health sciences, In vivo, estradiol, Internal medicine, medicine, Animalia, Animals, controlled study, RNA, Messenger, radioisotope, Liver X receptor, protein expression, DNA Primers, 030304 developmental biology, nonhuman, cesium 137, Rattus, animal model, Cholesterol side-chain cleavage enzyme, drinking water, Metabolism, cholesterol monooxygenase (side chain cleaving), enzyme linked immunosorbent assay, Rats, Endocrinology, food chain, chemistry, Nuclear receptor, 13. Climate action, gene expression, RNA, Farnesoid X receptor, Sprague-Dawley, farnesoid X receptor, Hormone
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0644927714928ba8c327f1ec41e5a750Test
https://doi.org/10.1007/s00204-007-0268-4Test -
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المصدر: Archives of Toxicology. 81:11-17
مصطلحات موضوعية: erythrocyte deformability, Erythrocyte Aggregation, Erythrocyte Indices, Male, Erythrocytes, Health, Toxicology and Mutagenesis, erythrocyte membrane, Blood viscosity, environmental exposure, animal cell, Hematocrit, Toxicology, Erythrocyte aggregation, Blood plasma, rat, aluminum sulfate, Mean corpuscular volume, Whole blood, blood rheology, mean corpuscular volume, medicine.diagnostic_test, Chemistry, article, Hematology, General Medicine, Red blood cell deformability, Blood Viscosity, medicine.anatomical_structure, priority journal, sodium chloride, Hemoglobinometry, Alum Compounds, blood sampling, Injections, Intraperitoneal, medicine.medical_specialty, animal experiment, hematological parameters, blood clotting, analyzer, shear stress, body weight, Erythrocyte Deformability, Internal medicine, medicine, Animals, Animalia, controlled study, Rats, Wistar, Plasma viscosity, nonhuman, Dose-Response Relationship, Drug, Rattus, animal model, Rats, Red blood cell, Endocrinology, aluminum, Hemorheology, viscometer, Immunology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab2765a0293dd73e34f4ff32e3b8225eTest
https://doi.org/10.1007/s00204-006-0119-8Test -
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المؤلفون: Jean-Marc A. Lobaccaro, E. Tissandie, Yann Gueguen, François Paquet, Jocelyne Aigueperse, Maâmar Souidi
المساهمون: Radiobiologie et épidémiologie (DRPH/SRBE), Institut de Radioprotection et de Sûreté Nucléaire (IRSN), Université Blaise Pascal - Clermont-Ferrand 2 (UBP), Service de RadioBiologie et d'Epidémiologie (IRSN/DRPH/SRBE)
المصدر: Archives of Toxicology
Archives of Toxicology, 2006, 80 (8), pp.473-480. ⟨10.1007/s00204-006-0068-2⟩مصطلحات موضوعية: Enzymologic, Male, 2 hydroxypropyl beta cyclodextrin, [SDV]Life Sciences [q-bio], Health, Toxicology and Mutagenesis, Messenger, Parathyroid hormone, vitamin D, radiation exposure, 010501 environmental sciences, Toxicology, 01 natural sciences, Rats, Sprague-Dawley, chemistry.chemical_compound, liver mitochondrion, Cytochrome P-450 Enzyme System, CYP27A1, rat, 0303 health sciences, Kidney, biology, messenger RNA, Reverse Transcriptase Polymerase Chain Reaction, article, General Medicine, enzyme activity, medicine.anatomical_structure, priority journal, real time polymerase chain reaction, uranyl nitrate, Toxicity, Vitamin, carbon 14, kidney, medicine.medical_specialty, colecalciferol, cytochrome P450, animal experiment, sterol 27 hydroxylase, liver, Gene Expression Regulation, Enzymologic, uranium, reverse transcription polymerase chain reaction, 03 medical and health sciences, vitamin D metabolism, CYP24A1, Internal medicine, medicine, Vitamin D and neurology, parathyroid hormone, Animals, controlled study, RNA, Messenger, 030304 developmental biology, 0105 earth and related environmental sciences, nonhuman, parathyroid hormone blood level, cholesterol, Cytochrome P450, Rats, Endocrinology, Gene Expression Regulation, chemistry, gene expression, biology.protein, RNA, calcium channel, Sprague-Dawley
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3770336e19c88eed855cb12d436e4deTest
https://doi.org/10.1007/s00204-006-0068-2Test -
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المؤلفون: Zafer Yonden, Vural Kucukatay, Aysel Agar, Namik Delibas, Oktay Hasan Ozturk, Huseyin Bagci
المصدر: Archives of toxicology. 80(10)
مصطلحات موضوعية: Male, Time Factors, hippocampus, Health, Toxicology and Mutagenesis, Toxicology, Hippocampus, chemistry.chemical_compound, sulfite, Cognition, rat, Receptor, Heme, chemistry.chemical_classification, article, General Medicine, Amino acid, enzyme activity, Biochemistry, priority journal, Liver, Toxicity, Mammalia, enzyme deficiency, down regulation, medicine.medical_specialty, n methyl dextro aspartic acid receptor 2B, n methyl dextro aspartic acid receptor 2A, animal experiment, Down-Regulation, Receptors, N-Methyl-D-Aspartate, animal tissue, sulfite oxidase, Sulfite, male, Sulfite oxidase, Internal medicine, medicine, Animalia, Animals, Sulfites, controlled study, Rats, Wistar, protein expression, nonhuman, animal model, Sulfite Oxidase, protein subunit, Metabolism, Rats, Protein Subunits, Enzyme, Endocrinology, chemistry, nervous system, ingestion
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c30239815c50f599a5b938a922d5c755Test
https://pubmed.ncbi.nlm.nih.gov/16858610Test -
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المؤلفون: Vural Kucukatay, Aysel Agar, Oguz K. Baskurt, Melek Bor-Kucukatay
المصدر: Archives of toxicology. 79(9)
مصطلحات موضوعية: erythrocyte deformability, Male, Health, Toxicology and Mutagenesis, medicine.medical_treatment, ex vivo study, animal cell, Pharmacology, Toxicology, alpha tocopherol, Sulfite oxidase, Antioxidants, chemistry.chemical_compound, sulfite, Erythrocyte deformability, Vitamin E, rat, rat strain, device, Chemistry, adult, article, General Medicine, Food additives, olive oil, medicine.anatomical_structure, Biochemistry, priority journal, Oxidation-Reduction, feeding, stomach, animal experiment, In Vitro Techniques, shear stress, in vivo study, Sulfite, In vivo, sodium metabisulfite, blood, Erythrocyte Deformability, medicine, Animals, Humans, Sulfites, controlled study, human, liquid, normal human, food additive, nonhuman, human cell, Sulfite Oxidase, drinking water, Sodium metabisulfite, Rats, Red blood cell, concentration response, exposure, Ex vivo
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e5bb6a4b2a74f963d6d836e1e4b2500Test
https://pubmed.ncbi.nlm.nih.gov/15827731Test -
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المؤلفون: Albert G. Hulst, L.P.A. de Jong, Daan Noort, A. Fidder, Hendrik P. Benschop
المساهمون: Prins Maurits Laboratorium TNO
المصدر: Archives of Toxicology, 4-5, 74, 207-214
مصطلحات موضوعية: Male, Lewisite, Globins, 9004-22-2, Erythrocytes, Unclassified drug, Health, Toxicology and Mutagenesis, Metabolite, Urine, Toxicology, Arsenicals, chemistry.chemical_compound, Hemoglobins, Carbon Radioisotopes, Whole blood, Gas chromatography-mass spectroscopy, Chelating Agents, Gas chromatography, Electrospray mass spectroscopy, Imidazoles, General Medicine, Environmental exposure, 2-chlorovinylarsonous acid, Globins, Erythrocyte, Biological monitoring, Radioactivity, Dimercaprol, Haemoglobin, medicine.drug, Human, Protein Binding, Spectrometry, Mass, Electrospray Ionization, 1-(heptafluorobutyryl)imidazole, 32477-35-3, Adducts, Arsenic acid derivative, Guinea Pigs, Urinalysis, 2 chlorovinylarsonous acid, Gas Chromatography-Mass Spectrometry, Health hazard, Electrospray ionization, medicine, Animals, Humans, Hemoglobin, Animal experiment, Derivatization, Imidazole derivative, Lewisite, 541-25-3, Chromatography, Binding Sites, Mass spectrometry, Dimercaprol, 59-52-9, Chemical warfare, Environmental Exposure, Guinea pig, Nonhuman, Beta globin, chemistry, Human cell, Quantitative analysis (chemistry), Controlled study
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70a85fb92f5d0c3b1af3def53be76d1eTest
https://pubmed.ncbi.nlm.nih.gov/10959794Test -
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المؤلفون: H. R. Immel, R. L. Zielhuis, G. G. De Schepper, A. J. J. Dietrich, A. A. E. Wibowo, M.I. Willems
المساهمون: Centraal Instituut voor Voedingsonderzoek TNO
المصدر: Archives of Toxicology, 2, 50, 149-157
مصطلحات موضوعية: Male, Erythrocytes, Health, Toxicology and Mutagenesis, Lymphocyte, Rabbit, Toxicology, Broxuridine, Crossing Over, Genetic, Lymphocytes, Sister chromatid exchange, Microscopy, Male genital system, Spermatozoon, Sperm Count, General Medicine, Anatomy, Lymphatic system, Spermatozoa, Erythrocyte, Zinc, medicine.anatomical_structure, Micronucleus test, Crossing Over (Genetics), Female, Rabbits, Cadmium, Blood and hemopoietic system, Histology, Bone Marrow Cells, Biology, Andrology, medicine, Organometallic Compounds, Sister chromatids, Animals, Bone marrow, Animal experiment, Support, Non-U.S. Gov't, Cell Nucleus, Animal, Mutagenicity Tests, Sperm, Micronucleus, Lead, Lead acetate, Sister Chromatid Exchange
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e44e341119e439a7291c090ca38a8c1Test
https://pubmed.ncbi.nlm.nih.gov/7125909Test