التفاصيل البيبلوغرافية
| العنوان: |
Chemobrain: mitoxantrone-induced oxidative stress, apoptotic and autophagic neuronal death in adult CD-1 mice. |
| المؤلفون: |
Dias-Carvalho, Ana, Ferreira, Mariana, Reis-Mendes, Ana, Ferreira, Rita, Bastos, Maria Lourdes, Fernandes, Eduarda, Sá, Susana Isabel, Capela, João Paulo, Carvalho, Félix, Costa, Vera Marisa |
| المصدر: |
Archives of Toxicology; Jun2022, Vol. 96 Issue 6, p1767-1782, 16p |
| مصطلحات موضوعية: |
OXIDATIVE stress, POSTSYNAPTIC density protein, DNA topoisomerase II, NITRIC-oxide synthases, ADENOSINE triphosphatase, DNA topoisomerase I, SUPEROXIDE dismutase, ENDOTHELIUM |
| مستخلص: |
Mitoxantrone (MTX) is a topoisomerase II inhibitor used to treat a wide range of tumors and multiple sclerosis but associated with potential neurotoxic effects mediated by hitherto poorly understood mechanisms. In adult male CD-1 mice, the underlying neurotoxic pathways of a clinically relevant cumulative dose of 6 mg/kg MTX was evaluated after biweekly administration for 3 weeks and sacrifice 1 week after the last administration was undertaken. Oxidative stress, neuronal damage, apoptosis, and autophagy were analyzed in whole brain, while coronal brain sections were used for a closer look in the hippocampal formation (HF) and the prefrontal cortex (PFC), as these areas have been signaled out as the most affected in 'chemobrain'. In the whole brain, MTX-induced redox imbalance shown as increased endothelial nitric oxide synthase and reduced manganese superoxide dismutase expression, as well as a tendency to a decrease in glutathione levels. MTX also caused diminished ATP synthase β expression, increased autophagic protein LC3 II and tended to decrease p62 expression. Postsynaptic density protein 95 expression decreased in the whole brain, while hyperphosphorylation of Tau was seen in PFC. A reduction in volume was observed in the dentate gyrus (DG) and CA1 region of the HF, while GFAP-ir astrocytes increased in all regions of the HF except in the DG. Apoptotic marker Bax increased in the PFC and in the CA3 region, whereas p53 decreased in all brain areas evaluated. MTX causes damage in the brain of adult CD-1 mice in a clinically relevant cumulative dose in areas involved in memory and cognition. [ABSTRACT FROM AUTHOR] |
|
Copyright of Archives of Toxicology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
