Prostanoid function and cardiovascular disease
| العنوان: | Prostanoid function and cardiovascular disease |
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| المؤلفون: | Manuel D. Díaz-Muñoz, Manuel Fresno, Miguel A. Iñiguez, Natalia Cuesta, Cristina Cacheiro-Llaguno |
| المصدر: | Archives of Physiology and Biochemistry. 114:201-209 |
| بيانات النشر: | Informa UK Limited, 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | medicine.medical_specialty, Physiology, Thromboxane, Prostaglandin, Prostacyclin, chemistry.chemical_compound, Physiology (medical), Internal medicine, medicine, Homeostasis, Humans, Platelet, business.industry, Prostanoid, General Medicine, Cardiovascular physiology, Endocrinology, Thromboxanes, Eicosanoid, chemistry, Cardiovascular Diseases, Prostaglandins, cardiovascular system, lipids (amino acids, peptides, and proteins), business, medicine.drug |
| الوصف: | Prostanoids, including prostaglandins (PGs) and thromboxanes (TXs) are synthesized from arachidonic acid by the combined action of cyclooxygenases (COXs) and PG and TX synthases. Finally after their synthesis, prostanoids are quickly released to the extracellular medium exerting their effects upon interaction with prostanoid receptors present in the neighbouring cells. These agents exert important actions in the cardiovascular system, modulating vascular homeostasis and participating in the pathogenesis of vascular diseases as thrombosis and atherosclerosis. Among prostanoids, Tromboxane (TX)A(2), a potent platelet activator and vasoconstrictor and prostacyclin (PGI2), a platelet inhibitor and vasodilator, are the most important in controlling vascular homeostasis. Although multiple studies using pharmacological inhibitors and genetically deficient mice have demonstrated the importance of prostanoid-mediated actions on cardiovascular physiology, further analysis on the prostanoid mediated actions in the vascular system are required to better understand the benefits and risks for the use of COX inhibitors in cardiovascular diseases. |
| تدمد: | 1744-4160 1381-3455 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d8dcc29e51f2f8777d9ae03197ee39eTest https://doi.org/10.1080/13813450802180882Test |
| رقم الانضمام: | edsair.doi.dedup.....3d8dcc29e51f2f8777d9ae03197ee39e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17444160 13813455 |
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