التفاصيل البيبلوغرافية
| العنوان: |
Exercise attenuates myocardial fibrosis and increases angiogenesis-related molecules in the myocardium of aged rats. |
| المؤلفون: |
Soori, Rahman, Amini, Arghavan Arab, Choobineh, Siroos, Eskandari, Arezoo, Behjat, Arezoo, Ghram, Amine, Voltarelli, Fabrício Azevedo |
| المصدر: |
Archives of Physiology & Biochemistry; Feb 2022, Vol. 128 Issue 1, p1-6, 6p |
| مصطلحات موضوعية: |
VASCULAR endothelial growth factors, HIGH-intensity interval training, FIBROSIS, MYOCARDIUM, EXERCISE therapy |
| مستخلص: |
The present study aimed to investigate the effect of two different exercise training protocols on myocardial fibrosis and the expression of some growth factors in aged rats. Twenty-four male Wistar rats were randomly assigned to high-intensity interval training (HIIT) group, continuous exercise training (CET) group, and the control group. After 6 weeks of experiment, mRNA levels of fibroblast growth factor-2 (FGF-2), vascular endothelial growth factor (VEGF), adropin proteins, and myocardial fibrosis were assessed. HIIT and CET induced a significant increase in the FGF-2 and adropin and a decrease in the myocardial fibrosis in compared with the control group. HIIT induced a significant increase in the VEGF if compared with the control group. There was no significant difference between CET and control group. Six weeks of HIIT and CET attenuated age-related myocardial fibrosis thereby an increase in angiogenesis-related molecules in cardiac and endothelial tissues. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
