التفاصيل البيبلوغرافية
| العنوان: |
[sub 1]-Weighted Spin-Echo Magnetic Resonance Images in Multiple Sclerosis: Relation to Inflammatory Activity. |
| المؤلفون: |
van Walderveen, Marianne A. A., Truyen, Luc, van Oosten, Bob W., Castelijns, Jonas A., Lycklama à Nijeholt, Geert J., van Waesberghe, Jan Hein T. M., Polman, Chris, Barkhof, Frederik |
| المصدر: |
Archives of Neurology; Mar1999, Vol. 56 Issue 3, p345, 7p |
| مصطلحات موضوعية: |
MULTIPLE sclerosis, GADOLINIUM, MAGNETIC resonance imaging |
| مستخلص: |
Objective: To evaluate whether degree of inflammatory activity in multiple sclerosis, expressed by frequency of gadolinium enhancement, has prognostic value for development of hypointense lesions on T[sub 1]-weighted spin-echo magnetic resonance images, a putative marker of tissue destruction. Design: Cohort design with long-term follow-up. Thirty-eight patients with multiple sclerosis who in the past had been monitored with monthly gadolinium-enhanced magnetic resonance imaging for a median period of 10 months (range, 6-12 months) were reexamined after a median period of 40.5 months (range, 33-80 months). Setting: Magnetic Resonance Center for Multiple Sclerosis Research, Amsterdam, the Netherlands, referral center. Main Outcome Measures: The new enhancing lesion rate (median number of gadolinium-enhancing lesions per monthly scan) during initial monthly follow-up; hypointense T[sub 1] and hyperintense T[sub 2] lesion load at first and last visit. Results: The number of enhancing lesions on entry scan correlated with the new enhancing lesions rate (r=0.64; P<.001, Spearman rank correlation coefficient). The new enhancing lesion rate correlated with yearly increase in T[sub 1] (r=0.42; P<.01, Spearman rank correlation coefficient) and T[sub 2] (r=0.47; P<.01, Spearman rank correlation coefficient) lesion load. Initial T[sub 1] lesion load correlated more strongly with yearly increase in T[sub 1] lesion load (r=0.68; P<.01, Spearman rank correlation coefficient). Conclusions: Degree of inflammatory activity only partially predicted increase in T[sub 1] (and T[sub 2]) lesion load at long-term follow-up. Initial T[sub 1] lesion load strongly contributed to subsequent increase in hypointense T[sub 1] lesion load, suggesting that there is a subpopulation of patients with multiple sclerosis who are prone to develop destructive lesions. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
