دورية
Increased leptin concentration in preterm infants of pre-eclamptic mothers.
| العنوان: | Increased leptin concentration in preterm infants of pre-eclamptic mothers. |
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| المؤلفون: | Hytinantti, T, Koistinen, H A, Koivisto, V A, Karonen, S L, Rutanen, E M, Andersson, S |
| المصدر: | Archives of Disease in Childhood. Fetal and Neonatal Edition; July 2000, Vol. 83 Issue: 1 pF13-6 |
| مستخلص: | AIM: To study the effect of maternal pre-eclampsia on cord plasma leptin concentrations in preterm infants. METHODS: Leptin concentration was analysed in cord plasma of 74 preterm infants, gestational age 24 to 32 weeks. Of these, 14 were born to pre-eclamptic mothers, in 10 intrauterine growth retardation (IUGR) was present, and 59 had been exposed antenatally to corticosteroids. RESULTS: The mean (SD) concentration of cord plasma leptin was 1.31 (0.88) microg/l. A significant correlation was found between leptin concentration and gestational age (r = 0.336; p = 0.0037). Leptin levels were higher in infants of pre-eclamptic mothers (p = 0.0007), in those with IUGR (p = 0.0005), and in infants exposed antenatally to corticosteroids (p = 0.02). In multiple regression analysis, leptin was associated with gestational age and maternal pre-eclampsia (both p < 0.05), but not with antenatal corticosteroids. CONCLUSIONS: Increased fetal leptin in maternal pre-eclampsia may reflect a physiological adaptation to fetal stress such as hypoxia. |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 13592998 14682052 |
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