التفاصيل البيبلوغرافية
| العنوان: |
Once daily insulin detemir in cystic fibrosis with insulin deficiency. |
| المؤلفون: |
Hameed S, Morton JR, Field PI, Belessis Y, Yoong T, Katz T, Woodhead HJ, Walker JL, Neville KA, Campbell TA, Jaffé A, Verge CF |
| المصدر: |
Archives of Disease in Childhood; May2012, Vol. 97 Issue 5, p464-467, 4p |
| مستخلص: |
The aim of this study was to determine if once daily insulin detemir reverses decline in weight and lung function in patients with cystic fibrosis (CF). 12 patients with early insulin deficiency and six with CF related diabetes (aged 7.2-18.1 years) were treated for a median of 0.8 years. Changes in weight and lung function following treatment were compared to pretreatment changes. Before treatment, the change in weight SD score ([Delta]WtSDS), percentage of predicted forced expiratory volume in 1 s ([Delta]%FEV(1)) and percentage of predicted forced vital capacity ([Delta]%FVC) declined in the whole study population (-0.45±0.38, -7.9±12.8%, -5.8±14.3%) and in the subgroup with early insulin deficiency (-0.41±0.43, -9.8±9.3%, -6.8±10.3%). Following treatment with insulin [Delta]WtSDS, [Delta]%FEV(1) and [Delta]%FVC significantly improved in the whole study population (+0.18±0.29 SDS, p=0.0001; +3.7±10.6%, p=0.007; +5.2±12.7%, p=0.013) and in patients with early insulin deficiency (+0.22±0.31 SDS, p=0.003; +5.3±11.5%, p=0.004; +5.8±13.4%, p=0.024). Randomised controlled trials are now needed. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
