Focused image-guided parathyroidectomy in the current management of primary hyperparathyroidism
| العنوان: | Focused image-guided parathyroidectomy in the current management of primary hyperparathyroidism |
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| المؤلفون: | Catherine Langusch, Kim Donoghue, Olov Norlén, Angela Titmuss, Albert Shun, Andrew J. A. Holland, Leigh Delbridge |
| المصدر: | Archives of Disease in Childhood. 100:924-927 |
| بيانات النشر: | BMJ, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Male, Parathyroidectomy, medicine.medical_specialty, Pediatrics, Hypercalcaemia, Adolescent, endocrine system diseases, Adenoma, medicine.medical_treatment, Tertiary referral hospital, Cohort Studies, medicine, Humans, Child, Retrospective Studies, business.industry, Retrospective cohort study, Hyperparathyroidism, Primary, medicine.disease, Surgery, Surgery, Computer-Assisted, Hypoparathyroidism, Pediatrics, Perinatology and Child Health, Etiology, Female, business, Primary hyperparathyroidism |
| الوصف: | ObjectivePrimary hyperparathyroidism (PHPT) in childhood and adolescence has been considered a different disease to that seen in adults, with predominantly familial aetiology mandating open exploration to exclude parathyroid hyperplasia in contrast to the adoption of focused image-guided parathyroidectomy (FP) in adults.Study designA retrospective cohort study in a tertiary referral hospital setting of all children and adolescents (ResultsOver the 35-year study period (1980–2014), there were 31 patients who underwent parathyroidectomy for PHPT. 3 patients were from known multiple endocrine neoplasia type 1 syndrome (MEN1) families, 3 had an isolated family history of PHPT and 25 were sporadic. In the sporadic group, 24 (96%) presented with symptomatic hypercalcaemia, affecting the gastrointestinal, musculoskeletal, genitourinary or neuropsychiatric systems. In the 25 patients with sporadic PHPT, nine (36%) had FP with a single adenoma removed with a 100% initial cure rate. Sixteen patients (64%) in the sporadic group had an open exploration: 14 had single gland disease while 2 patients required a second procedure to achieve a final cure rate of 100%. Of the three patients with MEN1, one was cured, one has persistent hyperparathyroidism after FP and the third has permanent hypoparathyroidism after open exploration.ConclusionsThe majority of children and adolescents with PHPT have symptomatic disease due to a single adenoma. They can therefore be managed in a similar fashion to their adult counterparts with preoperative localisation studies aiming to permit FP in a day case setting. |
| تدمد: | 1468-2044 0003-9888 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2ab9776e21b62a4c7d9618d7f7130c0Test https://doi.org/10.1136/archdischild-2014-308047Test |
| رقم الانضمام: | edsair.doi.dedup.....a2ab9776e21b62a4c7d9618d7f7130c0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14682044 00039888 |
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