التفاصيل البيبلوغرافية
| العنوان: |
Skin Manifestations and Vascular Endothelial Growth Factor Levels in POEMS Syndrome. |
| المؤلفون: |
Barete, Stéphane, Mouawad, Roger, Choquet, Sylvain, Viala, Karine, Leblond, Véronique, Musset, Lucile, Amoura, Zahir, Khayat, David, Francès, Camille |
| المصدر: |
Archives of Dermatology; Jun2010, Vol. 146 Issue 6, p615-623, 9p |
| مستخلص: |
Objectives: To investigate skin manifestations of the polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy, and skin changes (POEMS) syndrome and their correlation with serum vascular endothelial growth factor (s-VEGF-A) levels and to describe the impact of autologous peripheral blood stem cell transplantation (aPBSCT) on these manifestations and the correlation with s-VEGF-A levels. Design: Case series from January 1993 through June 2007. Setting: Hospitalized care in Assistance Publique- Hôpitaux de Paris in Pitié-Salpêtrière and Tenon hospitals. Patients: Twenty-three patients with POEMS syndrome, 10 of whom were clinically followed up after aPBSCT. Main Outcome Measures: Description and distribution of clinical lesions at POEMS syndrome diagnosis, skin evaluation after aPBSCT, and s-VEGF-A levels measured at POEMS syndrome diagnosis and after aPBSCT. Results: In 21 patients with skin manifestations at POEMS syndrome diagnosis, the most common skin manifestations were hemangiomas (18 patients [86%]), hyperpigmentation (16 [76%]), skin thickening (12 [57%]), acrocyanosis (12 [57%]), hypertrichosis (11 [52%]), acquired facial lipoatrophy (11 [52%]), and white nails (8 [38%]). The median s-VEGF-A level was not different between patients with and without skin manifestations except in those with hypertrichosis (P=.04). After aPBSCT, no significant correlation was observed between s-VEGF-A level decreases and response of skin manifestations, again except for hypertrichosis (P=.007). Conclusions: Acquired facial lipoatrophy and livedo should be added to the skin manifestations of POEMS syndrome. Despite a role of s-VEGF-A in various skin manifestations, the impact of s-VEGF-A level decreases on skin outcomes is weak after aPBSCT, mostly resulting in clinical stabilization. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
