Prognostic factors of paraneoplastic pemphigus
| العنوان: | Prognostic factors of paraneoplastic pemphigus |
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| المؤلفون: | Luc Thomas, Saskia Ingen-Housz-Oro, Sandy Léger, Gilles Chaumentin, Caroline Robert, Pierre-Jean Weiller, Philippe Courville, Fabienne Léonard, Pascal Joly, Laurent Machet, Stéphane Debarbieux, Estelle Houivet, M. Dandurand, Francis Carsuzaa, Jacqueline Chevrant-Breton, Jean-Philippe Arnault, François Aubin, Denis Jullien, Michel D'Incan, Gérard Guillet, Olivier Chosidow, Catherine Lok, Jean-Philippe Lacour, Vincent Ferranti, Danièle Gilbert, Damien Picard, Marie-Sylvie Doutre, I. Kupfer, Olivier Dereure, Jacques Benichou, Carle Paul, Béatrice Crickx, Emmanuel Delaporte, Jean-Michel Pignon, Ludovic Martin |
| المساهمون: | Physiopathologie et biothérapies des maladies inflammatoires et autoimmunes, Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Littoral, Environnement, Télédétection, Géomatique (LETG-Angers), Littoral, Environnement, Télédétection, Géomatique UMR 6554 (LETG), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Université d'Angers (UA)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université de Brest (UBO)-Université de Rennes 2 (UR2), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Géographie et d'Aménagement Régional de l'Université de Nantes (IGARUN), Université de Nantes (UN)-Université de Nantes (UN)-Université de Caen Normandie (UNICAEN), Université de Nantes (UN)-Université de Nantes (UN), Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC (EA 3181) (CEF2P / CARCINO), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Service de Dermatologie, Hôtel-Dieu, Hôpital Edouard Herriot [CHU - HCL], Hospices Civils de Lyon (HCL), Department of Dermatology, Université d'Angers (UA), Service de dermatologie, Département de médecine oncologique [Gustave Roussy], Institut Gustave Roussy (IGR)-Institut Gustave Roussy (IGR), Service de Dermatologie, Centre Hospitalier Sud, Hospices Civils, Lyon, Protéines de défense des réponses immune et inflammatoire : identification, régulation et rôles physiopathologiques, Unité de biostatistiques [CHU Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Université de Rouen Normandie ( UNIROUEN ), Normandie Université ( NU ) -Normandie Université ( NU ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Laboratoire d'Etudes Environnementales des Systèmes Anthropisés, Université d'Angers ( UA ), Carcinogénèse épithéliale : facteurs prédictifs et pronostiques - UFC ( CEF2P / CARCINO ), Centre Hospitalier Régional Universitaire [Besançon] ( CHRU Besançon ) -Université Bourgogne Franche-Comté ( UBFC ) -Université de Franche-Comté ( UFC ), Hospices Civils de Lyon ( HCL ), Institut Gustave Roussy ( IGR ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Université de Rouen Normandie ( UNIROUEN ), Normandie Université ( NU ) -Normandie Université ( NU ), Unité de biostatistiques [Rouen], CHU Rouen-Université de Rouen Normandie ( UNIROUEN ) |
| المصدر: | Archives of Dermatology-Chicago Archives of Dermatology-Chicago-, American Medical Association, 2012, pp.1-8. ⟨10.1001/archdermatol.2012.1830⟩ Archives of Dermatology-Chicago-, American Medical Association, 2012, pp.1-8. 〈10.1001/archdermatol.2012.1830〉 |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Male, Erythema, Paraneoplastic Syndromes, Kaplan-Meier Estimate, Severity of Illness Index, [ SDV.CAN ] Life Sciences [q-bio]/Cancer, 030207 dermatology & venereal diseases, Antibodies, Monoclonal, Murine-Derived, 0302 clinical medicine, Adrenal Cortex Hormones, Neoplasms, Erythema multiforme, Aged, 80 and over, Univariate analysis, integumentary system, Mortality rate, Castleman disease, Hazard ratio, General Medicine, Middle Aged, Prognosis, 3. Good health, 030220 oncology & carcinogenesis, Female, medicine.symptom, Rituximab, Immunosuppressive Agents, Adult, medicine.medical_specialty, Dystonin, [SDV.CAN]Life Sciences [q-bio]/Cancer, Nerve Tissue Proteins, Dermatology, 03 medical and health sciences, medicine, Humans, Immunologic Factors, Protein Precursors, Aged, Autoantibodies, Proportional Hazards Models, Retrospective Studies, Erythema Multiforme, Mucous Membrane, Proportional hazards model, business.industry, Plakins, Membrane Proteins, medicine.disease, Cytoskeletal Proteins, Paraneoplastic pemphigus, Desmoplakins, Multivariate Analysis, business, Carrier Proteins, Pemphigus |
| الوصف: | International audience; OBJECTIVE To identify the prognostic factors of overall survival in a series of patients with paraneoplastic pemphigus (PNP). DESIGN Multicenter retrospective cohort study. SETTING Twenty-seven dermatology departments in France. PATIENTS A total of 53 patients (31 men and 22 women; median age, 59 years; age range, 30-88 years) were diagnosed as having PNP between 1992 and 2010. MAIN OUTCOME MEASURES Overall Kaplan-Meier survival rates were estimated, and features associated with survival were assessed using univariate (log-rank test) and multivariate (Cox regression) analyses. RESULTS The study included 53 patients with PNP. Thirty-six patients (68%) died during the study. The 1-, 3-, and 5-year overall survival rates were 49%, 41%, and 38%, respectively. The main causes of death were infections (n = 21) and evolution of neoplasia (n = 6). In univariate analysis, the main detrimental prognostic factors identified were erythema multiforme-like skin lesions (P = .05) and histologic keratinocyte necrosis (P = .03). None of the 5 patients with Castleman disease died during the study. After adjustment for age and sex in multivariate analysis, erythema multiforme-like skin lesions remained predictive of fatal outcome, with a 2-fold increase in death rate (hazard ratio [HR], 2.3; 95% CI, 1.05-5.03; P = .04). The prognosis of patients with PNP was even poorer when erythema multiforme-like skin lesions were associated with severe skin or mucosal involvement at presentation (HR of death, 3.0; 95% CI, 1.01-8.92; P = .049). CONCLUSION Patients with PNP with erythema multiforme-like skin lesions and histologic keratinocyte necrosis, especially when associated with extensive lesions at presentation, are likely to have a more severe and rapid fatal outcome and should be managed very carefully. |
| تدمد: | 1538-3652 0003-987X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d384d5f4b897e1e15e66a84455120c23Test https://pubmed.ncbi.nlm.nih.gov/22801794Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d384d5f4b897e1e15e66a84455120c23 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15383652 0003987X |
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