المؤلفون: Green, Maxwell, Feschuk, Aileen M, Kashetsky, Nadia, Maibach, Howard I

المصدر: Archives of Dermatological Research. 315(6)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Clinical Sciences, Infectious Diseases, Aetiology, 2.1 Biological and endogenous factors, Humans, Male, Female, Young Adult, Adult, Antifungal Agents, Malassezia, Dermatomycoses, Folliculitis, Acne Vulgaris, Pruritus, Treatment Outcome, Pityrosporum folliculitis, Malassezia folliculitis, Acne vulgaris, Antifungal, Acneiform eruption, Dermatology & Venereal Diseases, Clinical sciences

الوصف: Pityrosporum folliculitis (PF) is a fungal acneiform disease of the hair follicles that often presents with pruritic papules and pustules on the upper body and face. This condition is commonly mistaken for acne vulgaris and can be distinguished from bacterial acne by the presence of fungal spores in the follicular lumen. Although studies have been performed to describe PF in cohorts, little work has been done to aggregate these data. Thus, the goal of this review is to describe the clinical characteristics and treatment outcomes of PF in immunocompetent patients. PubMed, Web of Science, and Embase were searched using the terms "Pityrosporum folliculitis" or "Malassezia folliculitis." All cohorts reporting PF characteristics in patients classified as immunocompetent were reviewed. A total of 15 studies were included. Majority of patients were male (64%) with the average age of presentation of 24.26 years. The most common locations of lesions were the chest (70%) and back/shoulders (69.2%). Pruritus was reported by the majority of patients (71.7%). Additionally, 40.5% of patients reported a history of unsuccessful treatment regimens. Treatment was most successful with an oral antifungal (92%), followed by a topical antifungal (81.6%). In conclusion, majority of patients with PF were younger males. Many patients were primarily treated incorrectly, suggesting the importance of proper diagnosis. PF may be distinguishable from acne vulgaris by the presence of pruritus or suggested when a new acneiform eruption develops following antibiotic therapy or immunosuppression. When properly diagnosed, majority of cases of PF achieve complete response with oral or topical antifungals.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/8zt7p8pzTest

المؤلفون: Minkis, Kira, Bolotin, Diana, Council, M Laurin, Bar, Anna, Farah, Ronda S, Kibbi, Nour, Miest, Rachel YN, Orringer, Jeffrey S, Ortiz, Arisa, Suozzi, Kathleen C, Vashi, Neelam A, Yoo, Simon S, Albrecht, Joerg, Blalock, Travis W, Bruce, Alison J, Deng, Min, Desai, Shraddha, Eshaq, Milad, Fiessinger, Lori A, Ghareeb, Erica, Greywal, Tanya, Hebert, Adelaide A, Hooper, Deirdre, Hordinsky, Maria, Hu, Jenny C, Jibbe, Atieh, Joo, Jayne, Kelly, Kristen M, Kenkare, Sonya, Khetarpal, Shilpi, Kole, Lauren CS, Kourosh, A Shadi, Kuhn, Helena, Lee, Kachiu C, Lucas, Roberta, Luke, Janiene, Mafee, Mariam, Mayo, Tiffany T, Nawas, Zeena Y, Olasz Harken, Edit B, Pearlstein, Michelle V, Petronic-Rosic, Vesna, Robinson, Carolyn A, Rogge, Megan N, Saikaly, Sami K, Schenck, Olivia L, Schlick, Cynthia A, Shahabi, Ladan, Shipp, Desmond M, Shive, Melissa, Silapunt, Sirunya, Stratman, Erik J, Sulewski, Ronald, Suggs, Amanda K, Tolaymat, Leila, Ward, Kimberley HM, Weinstein Velez, Mara, Zeichner, Joshua, Kang, Bianca Y, Ibrahim, Sarah A, Christensen, Rachel E, Anvery, Noor, Dirr, McKenzie A, Lawrence, Naomi, Alam, Murad

المصدر: Archives of Dermatological Research. 315(6)

مصطلحات موضوعية: Clinical Research, Quality Education, Humans, Internship and Residency, Dermatology, Patient Care, Societies, Medical, Needs, Gap, Resident, Cosmetic, Education, Clinical Sciences, Dermatology & Venereal Diseases

الوصف: Cosmetic dermatology is a key subspecialty of academic dermatology. As such, academic centers are expected to demonstrate excellence in the teaching of cosmetic dermatology skills to trainees, the clinical delivery of cosmetic dermatology services to patients, and the performance of clinical research that advances knowledge and uncovers new therapies in cosmetic dermatology. The Association of Academic Cosmetic Dermatology (AACD), a newly formed medical professional society, includes as its principal aims the support of all of these areas. AACD is comprised of group of board-certified dermatologists who teach cosmetic and laser dermatology at US dermatology residency programs. An expert panel constituted by the AACD recently convened a workshop to review gaps pertaining to academic cosmetic dermatology. This panel considered needs and potential corrective initiatives in three domains: resident education, patient experience, and clinical research. The work of the panel was used to develop a roadmap, which was adopted by consensus, and which will serve to guide the AACD moving forward.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/3gv9j1wtTest

المؤلفون: Minkis, Kira, Bolotin, Diana, Council, M Laurin, Bar, Anna, Farah, Ronda S, Kibbi, Nour, Miest, Rachel YN, Orringer, Jeffrey S, Ortiz, Arisa, Suozzi, Kathleen C, Vashi, Neelam A, Yoo, Simon S, Albrecht, Joerg, Blalock, Travis W, Bruce, Alison J, Deng, Min, Desai, Shraddha, Eshaq, Milad, Fiessinger, Lori A, Ghareeb, Erica, Greywal, Tanya, Hebert, Adelaide A, Hooper, Deirdre, Hordinsky, Maria, Hu, Jenny C, Jibbe, Atieh, Joo, Jayne, Kelly, Kristen M, Kenkare, Sonya, Khetarpal, Shilpi, Kole, Lauren CS, Kourosh, A Shadi, Kuhn, Helena, Lee, Kachiu C, Lucas, Roberta, Luke, Janiene, Mafee, Mariam, Mayo, Tiffany T, Nawas, Zeena Y, Olasz Harken, Edit B, Pearlstein, Michelle V, Petronic-Rosic, Vesna, Robinson, Carolyn A, Rogge, Megan N, Sachs, Dana L, Saikaly, Sami K, Schenck, Olivia L, Schlick, Cynthia A, Shahabi, Ladan, Shipp, Desmond M, Shive, Melissa, Silapunt, Sirunya, Suggs, Amanda K, Tolaymat, Leila, Ward, Kimberley HM, Weinstein Velez, Mara, Zeichner, Joshua, Kang, Bianca Y, Ibrahim, Sarah A, Christensen, Rachel E, Anvery, Noor, Dirr, McKenzie A, Lawrence, Naomi, Alam, Murad

المصدر: Archives of Dermatological Research. 315(5)

مصطلحات موضوعية: Clinical Research, Quality Education, Humans, Dermatology, Internship and Residency, Curriculum, Surveys and Questionnaires, Needs, Initiative, Academic, Cosmetic, Proceeding, Clinical Sciences, Dermatology & Venereal Diseases

الوصف: Cosmetic and laser procedures are increasingly popular among patients and are skills in which dermatologists are regarded as well trained. Most dermatology residents intend to incorporate cosmetic procedures into their practice and prefer to learn such procedures during residency through direct patient care. However, there are notable challenges in optimizing how residents are trained in cosmetic and laser dermatology. To address these barriers and elevate the practice of cosmetic dermatology in academic medicine, the Association of Academic Cosmetic Dermatology (AACD) was founded in 2021 as the lead professional society for dermatologists who direct the education of resident trainees in cosmetic and laser dermatology. The AACD, a group of board-certified dermatologists who teach cosmetic and laser dermatology to residents, aims to improve cosmetic dermatology education through collaboration, research, and advocacy.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/7qx1s16mTest

المؤلفون: Joo, Jayne, Pourang, Aunna, Tchanque-Fossuo, Catherine N, Armstrong, April W, Tartar, Danielle M, King, Thomas H, Sivamani, Raja K, Eisen, Daniel B

المصدر: Archives of Dermatological Research. 314(7)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Clinical Sciences, Clinical Research, Cancer, Clinical Trials and Supportive Activities, Aged, Cicatrix, Dermatologic Surgical Procedures, Female, Humans, Male, Skin, Soft Tissue Injuries, Suture Techniques, Treatment Outcome, Wound Healing, Cutaneous closure technique, Cutaneous surgery, Scar evaluation, Undermining, Wound tension, Dermatology & Venereal Diseases, Clinical sciences

الوصف: Undermining is thought to improve wound outcomes; however, randomized controlled data regarding its efficacy are lacking in humans. The objective of this randomized clinical trial was to determine whether undermining low to moderate tension wounds improves scar cosmesis compared to wound closure without undermining. Fifty-four patients, 18 years or older, undergoing primary linear closure of a cutaneous defect with predicted postoperative closure length of ≥ 3 cm on any anatomic site were screened. Four patients were excluded, 50 patients were enrolled, and 48 patients were seen in follow-up. Wounds were divided in half and one side was randomized to receive either no undermining or 2 cm of undermining. The other side received the unselected intervention. Three months, patients and 2 masked observers evaluated each scar using the Patient and Observer Scar Assessment Scale (POSAS). A total of 50 patients [mean (SD) age, 67.6 (11.5) years; 31 (64.6%) male; 48 (100%) white] were enrolled in the study. The mean (SD) sum of the POSAS observer component scores was 12.0 (6.05) for the undermined side and 11.1 (4.68) for the non-undermined side (P = .60). No statistically significant difference was found in the mean (SD) sum of the patient component for the POSAS score between the undermined side [15.9 (9.07)] and the non-undermined side [13.33 (6.20)] at 3 months. For wounds under low to moderate perceived tension, no statistically significant differences in scar outcome or total complications were noted between undermined wound halves and non-undermined halves.Trail Registry: Clinical trials.gov Identifier NCT02289859. https://clinicaltrials.gov/ct2/show/NCT02289859Test .

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/0463h5rsTest

المؤلفون: Eisen, Daniel Brian, Zhuang, Anne Rang, Hasan, Aliza, Sharon, Victoria Rose, Bang, Heejung, Crispin, Milene Kennedy

المصدر: Archives of Dermatological Research. 312(3)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Clinical Sciences, Comparative Effectiveness Research, Clinical Research, Clinical Trials and Supportive Activities, Absorbable Implants, Aged, Animals, Cicatrix, Dermatologic Surgical Procedures, Female, Humans, Male, Polypropylenes, Postoperative Complications, Skin, Suture Techniques, Sutures, Wound Healing, Suture material, Polypropylene, Fast absorbing gut, Cosmetic outcome, Dermatology & Venereal Diseases, Clinical sciences

الوصف: Mixed opinions exist regarding cosmetic outcomes of 5-0 fast absorbing plain (FG) gut relative to nonabsorbable suture material, such as 5-0 polypropylene (PP). High quality randomized trials comparing these two suture materials are lacking. To determine whether the use of PP during layered repair of linear cutaneous surgery wounds improves scar cosmesis compared to wound closure with FG. A randomized, split wound, comparative effectiveness trial was undertaken. Patients were evaluated 3 months after the intervention by two blinded physicians using the validated patient observer scar assessment scale (POSAS). Patient assessments were also captured using the same instrument as well as scar width and complications. The mean sum of the six components of the POSAS was 10.26 vs 12.74 for PP and FG, respectively, significantly (p

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/5gz844rxTest

المؤلفون: Park, Gil Soon, An, Min Kyun, Yoon, Ji Ha, Park, Seok Soon, Koh, Sung Hoon, Mauro, Theodora M, Cho, Eun Byul, Park, Eun Joo, Kim, Kwang Ho, Kim, Kwang Joong

المصدر: Archives of Dermatological Research. 311(10)

مصطلحات موضوعية: 2.1 Biological and endogenous factors, Aetiology, Botulinum Toxins, Type A, Cell Movement, Cell Proliferation, Cells, Cultured, Cicatrix, Hypertrophic, Extracellular Matrix, Fibroblasts, Humans, Interleukin-6, JNK Mitogen-Activated Protein Kinases, MAP Kinase Signaling System, Phosphorylation, Primary Cell Culture, Transforming Growth Factor beta1, Botulinum toxin type A, JNK signaling, Hypertrophic scar, Clinical Sciences, Dermatology & Venereal Diseases

الوصف: Hypertrophic scar is a dermal fibroproliferative disease characterized by the overproduction and deposition of extracellular matrix, and the hyperproliferation and enhanced angiogenesis of fibroblasts, along with their enhanced differentiation to myofibroblasts. Botulinum toxin type A shows potential for prevention of hypertrophic scar formation; however, its effectiveness in attenuating skin fibrosis and the related mechanism are unclear. In this study, human scar fibroblasts were cultured and stimulated with botulinum toxin type A, and the changes in fibroblast proliferation, migration, and protein expression of pro-fibrotic factors were evaluated with colorimetric, scratch, and enzyme-linked immunosorbent assays and western blotting, respectively. Botulinum toxin type A treatment decreased the proliferation and migration of human scar fibroblasts compared with those of untreated controls. Protein expression levels of pro-fibrotic factors (transforming growth factor β1, interleukin-6, and connective tissue growth factor) were also inhibited by botulinum toxin type A, whereas the JNK phosphorylation level was increased. Activation of the JNK pathway demonstrated the inhibitory effects of the toxin on human scar fibroblast proliferation and production of pro-fibrotic factors, suggesting that the suppressive effects of botulinum toxin type A are closely associated with JNK phosphorylation. Overall, this study showed that botulinum toxin type A has a suppressive effect on extracellular matrix production and scar-related factors in human scar fibroblasts in vitro, and that regulation of JNK signaling plays an important role in this process. Our results provide a theoretical basis, at the cellular level, for the therapeutic use of botulinum toxin type A.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/3jp1f7b8Test

المؤلفون: Menon, GK, Orsó, E, Aslanidis, Charalampos, Crumrine, D, Schmitz, G, Elias, Peter M

المصدر: Archives of Dermatological Research. 306(8)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Clinical Sciences, Aged, Biopsy, Female, Humans, Lipid Droplets, Lipid Metabolism, Microscopy, Electron, Middle Aged, Mixed Function Oxygenases, Mutation, Peroxisomal Targeting Signal 2 Receptor, Peroxisome Proliferator-Activated Receptors, Receptors, Cytoplasmic and Nuclear, Refsum Disease, Skin, Dermatology & Venereal Diseases, Clinical sciences

الوصف: Classic Refsum disease (RD) is a rare, autosomal recessively-inherited disorder of peroxisome metabolism due to a defect in the initial step in the alpha oxidation of phytanic acid (PA), a C16 saturated fatty acid with four methyl side groups, which accumulates in plasma and lipid enriched tissues (please see van den Brink and Wanders, Cell Mol Life Sci 63:1752-1765, 2006). It has been proposed that the disease complex in RD is in part due to the high affinity of phytanic acid for retinoid X receptors and peroxisome proliferator-activated receptors. Structurally, epidermal hyperplasia, increased numbers of cornified cell layers, presence of cells with lipid droplets in stratum basale and reduction of granular layer to a single layer have been reported by Blanchet-Bardon et al. (The ichthyoses, SP Medical & Scientific Books, New York, pp 65-69, 1978). However, lamellar body (LB) density and secretion were reportedly normal. We recently examined biopsies from four unrelated patients, using both OsO4 and RuO4 post-fixation to evaluate the barrier lipid structural organization. Although lamellar body density appeared normal, individual organelles often had distorted shape, or had non-lamellar domains interspersed with lamellar structures. Some of the organelles seemed to lack lamellar contents altogether, showing instead uniformly electron-dense contents. In addition, we also observed mitochondrial abnormalities in the nucleated epidermis. Stratum granulosum-stratum corneum junctions also showed co-existence of non-lamellar and lamellar domains, indicative of lipid phase separation. Also, partial detachment or complete absence of corneocyte lipid envelopes (CLE) was seen in the stratum corneum of all RD patients. In conclusion, abnormal LB contents, resulting in defective lamellar bilayers, as well as reduced CLEs, likely lead to impaired barrier function in RD.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/7st4q7nrTest

المؤلفون: Behne, Martin J, Sanchez, Susana, Barry, Nicholas P, Kirschner, Nina, Meyer, Wilfried, Mauro, Theodora M, Moll, Ingrid, Gratton, Enrico

المصدر: Archives of dermatological research. 303(2)

مصطلحات موضوعية: Epidermis, Keratinocytes, Animals, Mice, Calcium, Organic Chemicals, Microscopy, Electron, Transmission, Microscopy, Fluorescence, Biopsy, Staining and Labeling, Cell Membrane Permeability, Skin Absorption, Fourier Analysis, Male, Mice, Hairless, Lifetime imaging, Calcium Green 5N, DMSO, Phasor analysis, Microscopy, Electron, Transmission, Fluorescence, Hairless, Dermatology & Venereal Diseases, Clinical Sciences

الوصف: Calcium controls an array of key events in keratinocytes and epidermis: localized changes in Ca(2+) concentrations and their regulation are therefore especially important to assess when observing epidermal barrier homeostasis and repair, neonatal barrier establishment, in differentiation, signaling, cell adhesion, and in various pathological states. Yet, tissue- and cellular Ca(2+) concentrations in physiologic and diseased states are only partially known, and difficult to measure. Prior observations on the Ca(2+) distribution in skin were based on Ca(2+) precipitation followed by electron microscopy, or proton-induced X-ray emission. Neither cellular and/or subcellular localization could be determined through these approaches. In cells in vitro, fluorescent dyes have been used extensively for ratiometric measurements of static and dynamic Ca(2+) concentrations, also assessing organelle Ca(2+) concentrations. For lack of better methods, these findings together build the basis for the current view of the role of Ca(2+) in epidermis, their limitations notwithstanding. Here we report a method using Calcium Green 5N as the calcium sensor and the phasor-plot approach to separate raw lifetime components. Thus, fluorescence lifetime imaging (FLIM) enables us to quantitatively assess and visualize dynamic changes of Ca(2+) at light-microscopic resolution in ex vivo biopsies of unfixed epidermis, in close to in vivo conditions. Comparing undisturbed epidermis with epidermis following a barrier insult revealed major shifts, and more importantly, a mobilization of high amounts of Ca(2+) shortly following barrier disruption, from intracellular stores. These results partially contradict the conventional view, where barrier insults abrogate a Ca(2+) gradient towards the stratum granulosum. Ca(2+) FLIM overcomes prior limitations in the observation of epidermal Ca(2+) dynamics, and will allow further insights into basic epidermal physiology.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/52q0v783Test

المؤلفون: Rizzo, William B, S’Aulis, Dana, Jennings, M Anitia, Crumrine, Debra A, Williams, Mary L, Elias, Peter M

المصدر: Archives of Dermatological Research. 302(6)

مصطلحات موضوعية: Medical Physiology, Biomedical and Clinical Sciences, Pediatric, Adolescent, Adult, Aldehyde Oxidoreductases, Cell Membrane Permeability, Cell Surface Extensions, Cells, Cultured, Child, Child, Preschool, DNA Mutational Analysis, Epidermis, Female, Fibroblasts, Humans, Ichthyosis, Lamellar, Infant, Male, Mutation, Oxidation-Reduction, Secretory Pathway, Sjogren-Larsson Syndrome, Ichthyosis, Fatty alcohol, Fatty aldehyde, Aldehyde dehydrogenase, Stratum corneum, Genetic disease, Clinical Sciences, Dermatology & Venereal Diseases, Clinical sciences

الوصف: Sjögren-Larsson syndrome is a genetic disease characterized by ichthyosis, mental retardation, spasticity and mutations in the ALDH3A2 gene coding for fatty aldehyde dehydrogenase, an enzyme necessary for oxidation of fatty aldehydes and fatty alcohols. We investigated the cutaneous abnormalities in 9 patients with Sjögren-Larsson syndrome to better understand how the enzymatic deficiency results in epidermal dysfunction. Histochemical staining for aldehyde oxidizing activity was profoundly reduced in the epidermis. Colloidal lanthanum perfusion studies showed abnormal movement of tracer into the extracellular spaces of the stratum corneum consistent with a leaky water barrier. The barrier defect could be attributed to the presence of abnormal lamellar bodies, many with disrupted limiting membranes or lacking lamellar contents. Entombed lamellar bodies were present in the cytoplasm of corneocytes suggesting blockade of lamellar body secretion. At the stratum granulosum-stratum corneum interface, non-lamellar material displaced or replaced secreted lamellar membranes, and in the stratum corneum, the number of lamellar bilayers declined and lamellar membrane organization was disrupted by foci of lamellar/non-lamellar phase separation. These studies demonstrate the presence of a permeability barrier abnormality in Sjögren-Larsson syndrome, which localizes to the stratum corneum interstices and can be attributed to abnormalities in lamellar body formation and secretion.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/7bj0b0szTest

المؤلفون: Johannes M. Miocic, Franziska Schauer, Claudia Ansorge

المساهمون: Geo-Energy

المصدر: ARCHIVES OF DERMATOLOGICAL RESEARCH, 314, 427-437. SPRINGER

مصطلحات موضوعية: medicine.medical_specialty, PEMPHIGUS VULGARIS/FOLIACEUS, Universities, Chronic venous insufficiency, Epidemiology, Geriatric patients, MELANOMA, Type 2 diabetes, Dermatology, DIAGNOSIS, Skin Diseases, Comorbidities, Angina, 030207 dermatology & venereal diseases, 03 medical and health sciences, 0302 clinical medicine, Germany, Psoriasis, medicine, Humans, 030212 general & internal medicine, Medical diagnosis, Aged, Retrospective Studies, Geriatrics, RISK, Inpatients, business.industry, WOMEN, General Medicine, ASSOCIATION, medicine.disease, TRENDS, NMSC, Hospitalization, Diabetes Mellitus, Type 2, Cohort, S2K GUIDELINES, SQUAMOUS-CELL CARCINOMA, GENDER, business

الوصف: The demographic trend of an ageing society is mirrored in the rising number of hospitalized geriatric patients in Germany. However, there is still a wide gap of knowledge regarding the dermatological diseases, comorbidities and performed procedures within this growingly important group of patients. The study was conducted as a retrospective monocentric data analysis of all patients 65 years or older from the Department of Dermatology, Medical Center—University of Freiburg, Germany. In total, 10,009 individual hospitalisations were included from 2009 to 2017, and there was a notable increase of geriatric patients in the study period. This study illustrates the following: leading major diagnoses included malignant neoplasm of the head and neck, ulcerated and non-ulcerated inflammatory spectrum of chronic venous insufficiency, whereas angina pectoris, type 2 diabetes and cardiac diseases were noted most frequently as secondary diagnoses. Patients with venous diseases had considerably more often cardiopulmonary minor diagnoses, whereas endocrine diagnoses peaked in the cohort of patients with psoriasis and psychiatric and muscululoskeletal disorders in patients with bullous dieseases. Moh’s surgery, dressings and multimodal dermatological treatments were the most often encoded procedures.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::989a6797f314f8730d4daa67005b633fTest
https://hdl.handle.net/11370/2be2c4dd-e053-4228-a73f-f18930be6017Test