The effects of intracerebroventricularly applied ghrelin on thymocytes and thymic architecture in rats of different ages
| العنوان: | The effects of intracerebroventricularly applied ghrelin on thymocytes and thymic architecture in rats of different ages |
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| المؤلفون: | Jelena Lazic, Sanja Mazic, Dejan Žikić, Jovana Todorovic, Zorica Terzic Supic, Dejan Nesic |
| المصدر: | Archives of Biological Sciences, Vol 72, Iss 2, Pp 265-270 (2020) |
| بيانات النشر: | University of Belgrade, University of Novi Sad, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, medicine.medical_treatment, Growth hormone secretagogue receptor, General Biochemistry, Genetics and Molecular Biology, Immune system, Atrophy, thymus, Internal medicine, medicine, Receptor, lymphoid tissue, Saline, lcsh:QH301-705.5, Medulla, 2. Zero hunger, business.industry, digestive, oral, and skin physiology, intracerebroventricularly (icv), medicine.disease, Endocrinology, Lymphatic system, lcsh:Biology (General), ghrelin, thymocytes, Ghrelin, General Agricultural and Biological Sciences, business |
| الوصف: | Paper description: The growth hormone secretagogue receptor R1a, the receptor for ghrelin, is expressed in immune cells. The influence of intracerebroventricularly administered ghrelin (1 μg/day/rat for 5 days) to rats of different ages (peripubertal (5 weeks), young (2 months) and middle-aged (6 months; n=10 per group), on thymus mass and thymic architecture was examined. Intracerebroventricular application of ghrelin postponed thymic atrophy: the average weights of the thymuses were significantly higher in the ghrelin groups; ghrelin positively influenced the number of thymocytes and thymic structure. Our results point to a stimulatory effect of ghrelin on thymic size and function. Abstract: Ghrelin positively influences the total number of thymocytes and size of the thymus in 14-, 20- and 24-month-old rats. We examined the effect of centrally-applied ghrelin on thymus weight and structure in Wistar rats of different ages. The study included 30 male Wistar rats of three age groups: peripubertal (5-week-old rats), young (2 months) and adult (6 months). The animals of each age group were divided into control and experimental groups that were administered intracerebroventricularly (ICV) 1 μg ghrelin/5 μL saline daily for five consecutive days. Following treatment, the thymuses were isolated, weighed and processed for stereological analysis by the point-counting method. The average weights of the thymuses were significantly higher in the ghrelin groups with respect to control rats (5 weeks: 444.90±18.03 vs 365.00±18.63; 2 months: 354.30±13.77 vs 257.00±9.60; 6 months: 365.00±15.90 vs 225.00±7.03, p |
| اللغة: | English |
| تدمد: | 1821-4339 0354-4664 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8637111824d3980d85f44247b7134ebTest http://www.doiserbia.nb.rs/img/doi/0354-4664/2020/0354-46642000020T.pdfTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d8637111824d3980d85f44247b7134eb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18214339 03544664 |
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