مراجعة
Maternal obesity and placental function: impaired maternal-fetal axis.
| العنوان: | Maternal obesity and placental function: impaired maternal-fetal axis. |
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| المؤلفون: | Louwen, Frank, Kreis, Nina-Naomi, Ritter, Andreas, Yuan, Juping |
| المصدر: | Arch Gynecol Obstet ; ISSN:1432-0711 ; Volume:309 ; Issue:6 |
| بيانات النشر: | Springer |
| سنة النشر: | 2024 |
| المجموعة: | PubMed Central (PMC) |
| مصطلحات موضوعية: | Epigenetics, Immune cells, Inflammation, Maternal obesity, Oxidative stress, Placenta, Placental metabolism |
| الوصف: | The prevalence of maternal obesity rapidly increases, which represents a major public health concern worldwide. Maternal obesity is characteristic by metabolic dysfunction and chronic inflammation. It is associated with health problems in both mother and offspring. Increasing evidence indicates that the placenta is an axis connecting maternal obesity with poor outcomes in the offspring. In this brief review, we have summarized the current data regarding deregulated placental function in maternal obesity. The data show that maternal obesity induces numerous placental defects, including lipid and glucose metabolism, stress response, inflammation, immune regulation and epigenetics. These placental defects affect each other and result in a stressful intrauterine environment, which transduces and mediates the adverse effects of maternal obesity to the fetus. Further investigations are required to explore the exact molecular alterations in the placenta in maternal obesity, which may pave the way to develop specific interventions for preventing epigenetic and metabolic programming in the fetus. |
| نوع الوثيقة: | review article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.1007/s00404-024-07462-wTest; https://pubmed.ncbi.nlm.nih.gov/38494514Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11147848Test/ |
| DOI: | 10.1007/s00404-024-07462-w |
| الإتاحة: | https://doi.org/10.1007/s00404-024-07462-wTest https://pubmed.ncbi.nlm.nih.gov/38494514Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11147848Test/ |
| حقوق: | © 2024. The Author(s). |
| رقم الانضمام: | edsbas.FD2FA403 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s00404-024-07462-w |
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