التفاصيل البيبلوغرافية
| العنوان: |
Appraisal of sub-chronic exposure to lambada-cyhalothrin and/or methomyl on the behavior and hepato-renal functioning in Oreochromis niloticus: Supportive role of taurine-supplemented feed. |
| المؤلفون: |
Rahman, Afaf N. Abdel1 (AUTHOR) anoureldin@zu.edu.eg, Mohamed, Amany Abdel-Rahman1,2 (AUTHOR) aabdaziz@zu.edu.eg, Dahran, Naief3 (AUTHOR), Farag, Mohamed F.M.4 (AUTHOR), Alqahtani, Leena S.5 (AUTHOR), Nassan, Mohamed A.6 (AUTHOR), AlThobaiti, Saed Ayidh7 (AUTHOR), El-Naseery, Nesma I.8 (AUTHOR) |
| المصدر: |
Aquatic Toxicology. Sep2022, Vol. 250, pN.PAG-N.PAG. 1p. |
| مصطلحات موضوعية: |
*NILE tilapia, *GLUTATHIONE peroxidase, *BCL-2 proteins, *LACTATE dehydrogenase, *SUPEROXIDE dismutase, *ALKALINE phosphatase, *DIETARY supplements |
| مستخلص: |
• Lambada-cyhalothrin (LCT) and methomyl suppressed antioxidants and altered fish behavior. • LCT and MTM induced stress and histological architectural lesions in O. niloticus after 60 days exposure. • LCT and MTM enhanced the apoptosis in kidney and liver tissues and altered their implementation and capacity. • Taurine (TUR) supplementation in diet rescued the toxicological consequences of pesticides. • TUR-Supplemented diet is a natural promising candidate for aquaculture production. The existing study was designed to inspect the toxicological consequences of two pesticides; lambda-cyhalothrin (LCT) and methomyl (MTM) and their combination on Nile tilapia (Oreochromis niloticus) behaviors, oxidative stress, hepato-renal function indices and microarchitectural alterations. In addition, the efficiency of taurine (TUR) to rescue their toxicity was also considered. Juvenile O. niloticus were assigned into eight groups. The control and TUR groups were fed on a basal diet and TUR-enriched (10 g kg1) diet, respectively. The other groups were fed on a basal diet, and exposed to LCT (0.079 µg L–1), MTM (20.39 µg L–1 and (LCT + MTM). The last three groups were (LCT + TUR), (MTM + TUR), and (LCT + MTM + TUR) and fed on a TUR-enriched diet during exposure to LCT and/or MTM for 60 days. The exposure to LCT and/or MTM resulted in several behavioral alterations and stress via enhanced cortisol and nor-epinephrine levels. A significant elevation of serum 8-hydroxy-2- deoxyguanosine, aspartate and alanine aminotransferases, lactate dehydrogenase, Alkaline phosphatase, urea, creatinine was also observed in these groups. Furthermore, reduced antioxidant enzymes activities, including (catlase, glutathione peroxidase, and superoxide dismutase) with marked histopathological lesions in both liver and kidney tissues were detected. The up-regulated Bax and down-regulated Bcl-2 proteins were expressed in the liver and kidney tissues of LCT and/or MTM -exposed groups. Interestingly, all the observed alterations in behaviors, biochemical indices, and histo-architecture of renal and hepatic tissues were mitigated by TUR supplementation. The findings suggest that feeding O. niloticus dietary TUR may help to reduce the negative effects of LCT and/or MTM, and can also support kidney and liver health in O. niloticus, making it a promising aquaculture feed supplement. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
