Synthesis and characterization of a novel multi-functionalized reduced graphene oxide as a pH-sensitive drug delivery material and a photothermal candidate
| العنوان: | Synthesis and characterization of a novel multi-functionalized reduced graphene oxide as a pH-sensitive drug delivery material and a photothermal candidate |
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| المؤلفون: | Mirza-Aghayan, Maryam, Heidarian, Maryam, Mohammadi, Marzieh, Boukherroub, Rabah |
| المساهمون: | chemistry and chemical engineeting research center of Iran (CCERCI), CHEMISTRY AND CHEMICAL ENGINEERING, Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), NanoBioInterfaces - IEMN (NBI - IEMN), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), We thank Prof. Saeid Azizian from Bu-Ali Sina University for his valuable assistance in photothermal investigation. |
| المصدر: | Applied Surface Science Applied Surface Science, 2022, 583, pp.152568. ⟨10.1016/j.apsusc.2022.152568⟩ |
| بيانات النشر: | Elsevier BV, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | [SPI]Engineering Sciences [physics], Doxorubicin, Multi-functionalized reduced graphene oxide, Dopamine, Photothermal, Gold nanoparticles, General Physics and Astronomy, pH-sensitive, Drug release, Surfaces and Interfaces, General Chemistry, Condensed Matter Physics, Surfaces, Coatings and Films |
| الوصف: | International audience; In this work, we describe a simple and effective method for the synthesis of a novel multi-functionalized reduced graphene oxide (rGO/DA/Au NPs/DOX) through the successive reaction of graphene oxide (GO) with dopamine (DA), HAuCl4/NaBH4 and doxorubicin (DOX) under mild conditions. The rGO/DA/Au NPs/DOX hybrid nanomaterial was characterized by Fourier-transform infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM), energy dispersive X-ray (EDS), X-ray diffraction (XRD), Raman spectroscopy, transmission electron microscopy (TEM), atomic force microscopy (AFM), X-ray photoelectron spectroscopy (XPS), UV–visible absorption analyses, dispersion stability, zeta potential and dynamic light scattering (DLS) analysis. A good dispersion stability of rGO/DA/Au NPs/DOX material was observed with an average size of about 75 nm. The DOX loading capacity of rGO/DA/Au NPs was determined to be 0.852 mg/mg at an initial DOX concentration of 0.171 mg/mL. Then, the rGO/DA/Au NPs/DOX was explored for DOX release under various pH values of 9.4, 7.4 and 5.4. It was found that the rate of DOX release from the rGO/DA/Au NPs/DOX hybrid nanomaterial was pH-dependent with a DOX release of 67% under acidic (pH = 5.4) conditions. Due to the different DOX release rates under different pH values, the multi-functionalized rGO can be used as a suitable candidate material for intelligent drug release. The photothermal properties of rGO/DA/Au NPs/DOX hybrid nanomaterial were assessed under simulated solar sun irradiation. A rapid increase of the temperature was recorded upon irradiation, suggesting that rGO/DA/Au NPs/DOX hybrid material has good potential as a new photothermal agent. |
| تدمد: | 0169-4332 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b16b7db385956e1f57388477205994ecTest https://doi.org/10.1016/j.apsusc.2022.152568Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....b16b7db385956e1f57388477205994ec |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 01694332 |
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