التفاصيل البيبلوغرافية
| العنوان: |
Engineering microstructure of hydroxyapatite by electron beam irradiation to induce controllable in vitro degradation. |
| المؤلفون: |
Zhu, Hui1,2 (AUTHOR) juerry0330@stu.xjtu.edu.cn, Zheng, Kai2 (AUTHOR) kai.zheng@fau.de, Guo, Dagang1 (AUTHOR) guodagang@mail.xjtu.edu.cn, Zang, Hang1,3 (AUTHOR) zanghang@mail.xjtu.edu.cn, Yu, Sen4 (AUTHOR) yus@c-nin.com, Xu, Kewei1 (AUTHOR) kwxu@mail.xjtu.edu.cn |
| المصدر: |
Applied Surface Science. Oct2020, Vol. 528, pN.PAG-N.PAG. 1p. |
| مصطلحات موضوعية: |
*ELECTRON beams, *CRYSTAL defects, *IRRADIATION, *ABSORBED dose, *BONE substitutes |
| مستخلص: |
• The in vitro degradation of hydroxyapatite (HA) is improved by electron beam irradiation for the first time. • The in vitro degradation rate of HA increases as the irradiation dose increases. • The microstructure of HA can be engineered by electron beam irradiation. • The mechanism of enhanced HA dissolution has been revealed. • The irradiated HA is biocompatible. Controllable degradation behavior of hydroxyapatite (HA) plays a crucial role in successful long-term implantation of a bone tissue substitute. In this study, electron beam irradiation (EBI) was carried out as an efficient strategy to modify HA structure. The degradation characteristics, bioactivity and cell response of the irradiated HA were comprehensively evaluated. The results showed that EBI with absorbed dose of 3.42, 10.27 and 20.54 Gy did not introduce newly-formed phase or impurity, but created crystal defects and nanovoids, which were formed from oxygen deficiencies, into HA lattice with irradiation dose-dependence. The dissolution rate of the irradiated HA enhanced continuously with increasing irradiation dose, as a result of constantly increasing crystal defects and enlarging voids, where the main reactive sites for the degradation of HA formed. The Ca2+ and PO 4 3- releasing of HA with the highest irradiation dose enhanced by 92.75% and 138.85% respectively compared to that of the pristine HA after 28 days' immersion. SBF immersion results suggested the irradiated HA with raising EBI doses exhibited preferable performance in bioactivity as well. Moreover, the results from CCK-8 assay and SEM observation showed that the irradiated HA were beneficial to the proliferation and attachment of osteoblasts. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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