Transbulbar B-Mode Sonography for Clinical Phenotyping Multiple Sclerosis
| العنوان: | Transbulbar B-Mode Sonography for Clinical Phenotyping Multiple Sclerosis |
|---|---|
| المؤلفون: | Antonella De Donno, Roberto De Masi, Pantaleo Spagnolo, Sergio Pasca, Rocco Scarpello, Aldo Conte, Stefania Orlando |
| المساهمون: | De Masi, Roberto, Orlando, Stefania, Conte, Aldo, Pasca, Sergio, Scarpello, Rocco, Spagnolo, Pantaleo, De Donno, Antonella |
| المصدر: | Applied Sciences Volume 8 Issue 11 Applied Sciences, Vol 8, Iss 11, p 2177 (2018) |
| بيانات النشر: | Multidisciplinary Digital Publishing Institute, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | medicine.medical_specialty, Optic nerve sheath, Optic nerve, transbulbar B-mode sonography, 030204 cardiovascular system & hematology, multiple sclerosis, Gastroenterology, lcsh:Technology, optic nerve, Optic neuropathy, lcsh:Chemistry, 03 medical and health sciences, 0302 clinical medicine, Engineering (all), high-resolution ultrasound, Internal medicine, medicine, Rr- phenotype, General Materials Science, Multiple sclerosi, Secondary progressive, Instrumentation, lcsh:QH301-705.5, Subclinical infection, Fluid Flow and Transfer Processes, Expanded Disability Status Scale, business.industry, lcsh:T, Multiple sclerosis, Process Chemistry and Technology, General Engineering, High-resolution ultrasound, Computer Science Applications1707 Computer Vision and Pattern Recognition, medicine.disease, Transbulbar B-mode sonography, lcsh:QC1-999, Computer Science Applications, lcsh:Biology (General), lcsh:QD1-999, lcsh:TA1-2040, Materials Science (all), business, lcsh:Engineering (General). Civil engineering (General), 030217 neurology & neurosurgery, lcsh:Physics |
| الوصف: | The aim of this study was to assess putative differences in optic nerve sheath diameter (ONSD) and associated clinical/paraclinical variables between relapsing remitting (RR) and secondary progressive (SP) multiple sclerosis (MS) patients. We examined 60 relapse-free MS patients and 35 healthy controls by means of transbulbar B-mode sonography (TBS). Expanded disability status scale (EDSS) values were from 3 to 4 indicated patients with a transitional RR to SP phenotype. Mean ONSD was significantly lower in MS patients. Mean ONSD measured at 5 mm from the eyeball (ONSD5) was significantly lower in SP than in RR patients, while ONSD measured at 3 mm from the eyeball (ONSD3) was statistically higher in RR than in the transitional group. The myelination index (MI), i.e., the ratio of ONSD3 to ONSD5, was used to assess the relative myelination of the optic nerve (ON). Higher ONSD5 and MI (0.90) corresponded to patients with the RR phenotype having a mean EDSS of 2.0 lower MI (0.84) clustered the transitional patients having a mean EDSS of 3.7. Finally, lower MI with low ONSD3 identified the SP phenotype having a mean EDSS &ge 4.0. The TBS in MS highlights chronic optic neuropathy, caused by early subclinical axonal loss and demyelination. |
| وصف الملف: | application/pdf; ELETTRONICO |
| اللغة: | English |
| تدمد: | 2076-3417 |
| DOI: | 10.3390/app8112177 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b5a5c0b116b319d24db7b25534d529baTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....b5a5c0b116b319d24db7b25534d529ba |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20763417 |
|---|---|
| DOI: | 10.3390/app8112177 |