المؤلفون: Ann-Kristin Panknin, Bernd Schultes, Sebastian M. Schmid, Felix de Courbière, Manfred Hallschmid, Britta Wilms, Kamila Jauch-Chara, Hendrik Lehnert

المصدر: Appetite 105, 562-566 (2016)

مصطلحات موضوعية: Adult, Blood Glucose, Male, medicine.medical_specialty, Hunger, Appetite, Insulin, Nutritional Sensing, Satiety, medicine.medical_treatment, media_common.quotation_subject, Satiation, 030204 cardiovascular system & hematology, Affect (psychology), Body Mass Index, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, Endocrine system, Single-Blind Method, Infusions, Intravenous, Saline, General Psychology, Breakfast, Glycemic, media_common, Cross-Over Studies, Nutrition and Dietetics, Appetite Regulation, business.industry, Postprandial Period, Crossover study, Diet, Glucose, Endocrinology, business, Body mass index, 030217 neurology & neurosurgery

الوصف: Meal-dependent fluctuations of blood glucose and corresponding endocrine signals such as insulin are thought to provide important regulatory input for central nervous processing of hunger and satiety. Since food intake also triggers the release of numerous gastrointestinal signals, the specific contribution of changes in blood glucose to appetite regulation in humans has remained unclear. Here we tested the hypothesis that inducing glycemic fluctuations by intravenous glucose infusion is associated with concurrent changes in hunger, appetite, and satiety. In a single blind, counter-balanced crossover study 15 healthy young men participated in two experimental conditions on two separate days. 500ml of a solution containing 50g glucose or 0.9% saline, respectively, was intravenously infused over a 1-h period followed by a 1-h observation period. One hour before start of the respective infusion subject had a light breakfast (284kcal). Blood glucose and serum insulin concentrations as well as self-rated feelings of hunger, appetite, satiety, and fullness were assessed during the entire experiment. Glucose as compared to saline infusion markedly increased glucose and insulin concentrations (peak glucose level: 9.7±0.8 vs. 5.3±0.3mmol/l; t(14)=-5.159, p 

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::655c72f2b167926ec76f940a357959e1Test
https://doi.org/10.1016/j.appet.2016.06.032Test

المؤلفون: Sebastian M. Schmid, Manfred Hallschmid, Bernd Schultes, Britta Wilms, Kamila Jauch-Chara, Kerstin M. Oltmanns

المصدر: Appetite. 58(3)

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, medicine.medical_treatment, media_common.quotation_subject, Appetite, Anorexia, Hypoglycemia, chemistry.chemical_compound, Eating, Young Adult, Reference Values, Internal medicine, medicine, Humans, Insulin, Lactic Acid, Saline, General Psychology, media_common, Nutrition and Dietetics, business.industry, Fasting, Feeding Behavior, Glucose clamp technique, medicine.disease, Lactic acid, Endocrinology, chemistry, Hyperlactatemia, medicine.symptom, business, Energy Intake

الوصف: Considering that lactate is known to interact with central glucose-sensing networks, we tested whether hyperlactatemia affects food intake in humans. According to a balanced within-subject 2×2 design, 12 healthy, fasted men (age: 20-40 years; BMI: 20-26 kg/m(2)) were intravenously infused lactate and saline, respectively, for 105 min during concomitant euglycemic and hypoglycemic, respectively, insulin infusion of 75 min. Ten minutes after the simultaneous end of infusions, free-choice food intake was assessed at 10:25 h. Lactate decreased food intake following euglycemia as compared to the other three conditions in which food intake did not differ. Results point to an anorexigenic effect of lactate under euglycemic conditions.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ddca72eb4d99ff54c38fed6414c4f65Test
https://pubmed.ncbi.nlm.nih.gov/22314041Test