The influence of exposure to immunosuppressive treatment during pregnancy on renal function and rate of apoptosis in native kidneys of female Wistar rats
| العنوان: | The influence of exposure to immunosuppressive treatment during pregnancy on renal function and rate of apoptosis in native kidneys of female Wistar rats |
|---|---|
| المؤلفون: | Joanna Kabat-Koperska, Krzysztof Safranow, Kazimierz Ciechanowski, Anna Pilutin, Irena Baranowska-Bosiacka, Danuta Kosik-Bogacka, Edyta Gołembiewska, Karolina Kędzierska, Izabela Gutowska, Agnieszka Kolasa-Wołosiuk |
| المصدر: | Apoptosis |
| بيانات النشر: | Springer US, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, medicine.medical_specialty, Cancer Research, Clinical Biochemistry, 030232 urology & nephrology, Renal function, Pharmaceutical Science, Apoptosis, Mycophenolate, Kidney, Kidney Function Tests, Article, Tacrolimus, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Prednisone, Pregnancy, Internal medicine, medicine, Animals, Everolimus, Rats, Wistar, Pharmacology, Biochemistry, medical, Creatinine, Transplantation, business.industry, Biochemistry (medical), Cell Biology, Mycophenolic Acid, Rats, Calcineurin, Wistar rats, 030104 developmental biology, medicine.anatomical_structure, Endocrinology, chemistry, Immunosuppressive drugs, Cyclosporine, Female, business, Immunosuppressive Agents, medicine.drug |
| الوصف: | Pregnancy puts a significant additional strain on kidneys. The aim of our study was to investigate the impact of immunosuppressive drugs on changes in native kidneys in female Wistar rats after exposure during pregnancy. The study was conducted on 32 dams, subjected to immunosuppressive regimens commonly used in the therapy of human kidney transplant recipients (cyclosporine A, mycophenolate mofetil and prednisone; tacrolimus, mycophenolate mofetil and prednisone; cyclosporine A, everolimus and prednisone). The animals received drugs for 2 weeks before pregnancy and during 3 weeks of pregnancy. In all treated dams lower body weight (but not kidney mass) and alterations in serum sodium and chloride ions were found; serum creatinine concentration was increased in dams treated with cyclosporine A, everolimus and prednisone. All treatment groups of dams showed increased apoptosis in the distal tubules. In histological examination the changed intensity of acidophilic or basophilic cytoplasm of epithelial cells was found in kidneys of rats treated with calcineurin inhibitors, mycophenolate mofetil and prednisone. All immunosuppressive regimens caused abnormalities affecting nephron tubules. Regimens containing calcineurin inhibitors and mycophenolate mofetil caused higher rate of apoptosis and more pronounced histopathological changes. Regimen based on everolimus despite the lower rate of apoptosis in the proximal tubules and lower accumulation of kidney injury markers revealed higher serum creatinine concentration. Thus, interpretation which combination of drugs is better or worse for long-lasting functioning of kidneys in pregnant females requires further studies. |
| اللغة: | English |
| تدمد: | 1573-675X 1360-8185 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb166aabfeafadb67f0be5cc7d1c2adbTest http://europepmc.org/articles/PMC5047933Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fb166aabfeafadb67f0be5cc7d1c2adb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1573675X 13608185 |
|---|