Expression of activated signal transducer and activator of transcription 3 predicts poor clinical outcome in gastric adenocarcinoma
| العنوان: | Expression of activated signal transducer and activator of transcription 3 predicts poor clinical outcome in gastric adenocarcinoma |
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| المؤلفون: | Jeeyun Lee, Jae Moon Bae, Min Gew Choi, Joon Oh Park, Jeehyun Kong, Cheol Keun Park, Sung Kim, Young Suk Park, Junga Kim, Jae Hyung Noh, Kyoung-Mee Kim, Ho Yeong Lim, Won Ki Kang, Tae Sung Sohn, Se Hoon Park, Do Hoon Lim |
| المصدر: | APMIS. 117:598-606 |
| بيانات النشر: | Wiley, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Adult, Male, STAT3 Transcription Factor, Microbiology (medical), medicine.medical_specialty, Pathology, Survivin, Vascular Endothelial Growth Factor C, Adenocarcinoma, Gastroenterology, Inhibitor of Apoptosis Proteins, Pathology and Forensic Medicine, chemistry.chemical_compound, Matrix Metalloproteinase 10, Stomach Neoplasms, Internal medicine, Biomarkers, Tumor, medicine, Adjuvant therapy, Humans, Immunology and Allergy, Cyclin D1, Stomach cancer, STAT3, Aged, Univariate analysis, biology, business.industry, Hazard ratio, Cancer, General Medicine, Middle Aged, Prognosis, Vascular Endothelial Growth Factor Receptor-3, medicine.disease, Vascular endothelial growth factor, Matrix Metalloproteinase 9, chemistry, Tissue Array Analysis, Multivariate Analysis, biology.protein, Female, business, Microtubule-Associated Proteins |
| الوصف: | Lee J, Kang WK, Park JO, Park SH, Park YS, Lim HY, Kim J, Kong J, Choi MG, Sohn TS, Noh JH, Bae JM, Kim S, Lim DH, Kim K-M, Park CK. Expression of activated signal transducer and activator of transcription 3 predicts poor clinical outcome in gastric adenocarcinoma. APMIS 2009; 117: 598–606. There are no known reliable biomarkers which can predict poor clinical outcome following curative resection of gastric adenocarcinoma. Given the importance of signal transducer and activator of transcription 3 (STAT3) activation in carcinogenesis, we attempted to determine whether STAT3 activation is prognostic of survival in curatively resected gastric cancer patients. We analyzed 311 surgically resected gastric cancer specimens for STAT3 activation and its downstream molecules such as matrix metalloproteinase (MMP)-9, MMP-10, cyclin D1, survivin, vascular endothelial growth factor (VEGF)-C, and VEGFR-3 using immunohistochemical studies and assessed their correlation with clinical outcome. Using immunohistochemistry, 303 specimens were interpretable for pSTAT3tyr705 expression. The pSTAT3 was detected in 79 (26.1%) of 303 gastric cancers. Of the downstream molecules tested, STAT3 activation was significantly associated with MMP-9 and MMP-10 expressions. On univariate analyses, 5-year disease-free survival (DFS) and overall survival (OS) for the tumors with STAT3 activation were considerably poorer than for those without STAT3 activation with statistical significance (5-year DFS 58.2% vs 68.3%; pSTAT3(−) vs pSTAT3(+); p = 0.0223; 5-year OS 59.5% vs 70.5%; pSTAT3(−) vs pSTAT3(+); p = 0.0128). On multivariate analyses, STAT3 activation was independently associated with inferior DFS (p = 0.049, hazard ratio [HR] = 1.445, 95% CI, 1.025, 2.120) along with AJCC stage IIIA or IIIB (p = 0.004, HR = 1.708, 95% CI, 1.178, 2.475). The STAT3 activation was also strongly correlated with inferior OS (p = 0.042, HR = 1.506, 95% CI, 1.025, 2.213). Based on our data, pSTAT3tyr705 may be a novel prognostic marker for poorer clinical outcome following curative resection and adjuvant therapy in gastric cancer. The clinical impact of a STAT3-targeted agent should be investigated in gastric cancer patients. |
| تدمد: | 1600-0463 0903-4641 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13bb098b85de24707e6ee1c926f7cca9Test https://doi.org/10.1111/j.1600-0463.2009.02512.xTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....13bb098b85de24707e6ee1c926f7cca9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16000463 09034641 |
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