Multiple and bilateral kidney tumors with clear cells of three different histotypes: A case report with clinicopathologic and molecular study
| العنوان: | Multiple and bilateral kidney tumors with clear cells of three different histotypes: A case report with clinicopathologic and molecular study |
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| المؤلفون: | Maria Rosaria Raspollini, Liang Cheng, Rodolfo Montironi, Francesca Castiglione, Guido Martignoni, Antonio Lopez-Beltran, Alberto Lapini |
| المصدر: | APMIS. 124:619-623 |
| بيانات النشر: | Wiley, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Microbiology (medical), Neuroblastoma RAS viral oncogene homolog, Pathology, medicine.medical_specialty, medicine.disease_cause, Pathology and Forensic Medicine, 03 medical and health sciences, 0302 clinical medicine, medicine, Immunology and Allergy, neoplasms, Kidney, Molecular pathology, business.industry, General Medicine, Clear cell papillary renal cell carcinoma, medicine.disease, Clear cell renal cell carcinoma, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Immunohistochemistry, KRAS, business, Clear cell |
| الوصف: | We describe a rare multicentric neoplastic disease arising bilteraly in the kidney. The patient was a 70-year-old man, who, during a period of 3 years, was treated for five independent tumors of three histotypes (three multilocular cystic clear cell renal cell neoplasms of low malignant potential, one clear cell renal cell carcinoma, and one clear cell papillary renal cell carcinoma, respectively). Pathologic diagnosis of the reported tumors was confirmed by immunohistochemical analyses, including CD10, CA IX, CK7, AMACR/RACEMASE, and 34 beta E12. Molecular detection of KRAS, BRAF, NRAS, PIK3CA, ALK, ERBB2, DDR2, MAP2K1, RET, and EGFR gene mutational analysis was also performed in all tumors. |
| تدمد: | 0903-4641 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::0461932f00641a2947bf4e3788d69e85Test https://doi.org/10.1111/apm.12536Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........0461932f00641a2947bf4e3788d69e85 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09034641 |
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