Does HIV Infection Promote Early Kidney Injury in Women?
| العنوان: | Does HIV Infection Promote Early Kidney Injury in Women? |
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| المؤلفون: | Michael J. Bennett, Chirag R. Parikh, Marek Nowicki, Rebecca Scherzer, Vasantha Jotwani, Prasad Devarajan, Michael G. Shlipak, Kathryn Anastos, Anjali Sharma, Mary Young, Mardge H. Cohen, Michelle M. Estrella, Phyllis C. Tien, Alison G. Abraham, Carl Grunfeld |
| المصدر: | Antiviral therapy, vol 19, iss 1 |
| بيانات النشر: | SAGE Publications, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Kidney Disease, HIV Infections, Urine, Gastroenterology, chemistry.chemical_compound, Risk Factors, Antiretroviral Therapy, Highly Active, Receptors, Medicine, Pharmacology (medical), Prospective Studies, Hepatitis A Virus Cellular Receptor 1, Prospective cohort study, Kidney, Membrane Glycoproteins, Interleukin-18, Viral Load, Middle Aged, Virus, Infectious Diseases, medicine.anatomical_structure, Medical Microbiology, Creatinine, Receptors, Virus, HIV/AIDS, Kidney Diseases, Female, medicine.symptom, Infection, Viral load, Adult, medicine.medical_specialty, Clinical Sciences, Renal and urogenital, Antiretroviral Therapy, Renal function, Microbiology, Article, Young Adult, Virology, Internal medicine, Diabetes mellitus, Humans, Albuminuria, Highly Active, Aged, Pharmacology, business.industry, medicine.disease, CD4 Lymphocyte Count, Cross-Sectional Studies, Good Health and Well Being, chemistry, Immunology, business, Biomarkers |
| الوصف: | Background In HIV-infected women, urine concentrations of novel tubulointerstitial injury markers, interleukin-18 (IL-18) and kidney injury marker-1 (KIM-1), are associated with kidney function decline and all-cause mortality. We hypothesized that HIV-infected individuals with preserved kidney filtration function would have more extensive kidney injury, as determined by urine injury markers, compared to the uninfected controls, and that risk factors for tubulointerstitial injury would differ from risk factors for albuminuria. Methods In this cross-sectional study, we compared urine concentrations of IL-18, KIM-1 and albumin-to-creatinine ratio (ACR) in 908 HIV-infected and 289 HIV-uninfected women enrolled in the Women's Interagency HIV Study, utilizing stored urine specimens from visits between 1999 and 2000. Results After multivariate-adjusted linear regression analysis, mean urine concentrations were higher in HIV-infected individuals by 38% for IL-18 ( P+ lymphocyte count (8% per doubling; P=0.0025), HCV infection (30%; P=0.00018) and lower high-density lipoprotein (5% per 10 mg/dl; P=0.0024) were each associated with higher IL-18 concentrations. In contrast, hypertension (81%; PConclusions HIV-infected women had more extensive tubulointerstitial and glomerular injury than uninfected women, but the associated factors differed among the urine biomarkers. Combinations of urinary biomarkers should be investigated to further characterize early kidney injury in HIV-infected women. |
| وصف الملف: | application/pdf |
| تدمد: | 2040-2058 1359-6535 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3793a833d910952bc91e9ce36bd36642Test https://doi.org/10.3851/imp2677Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....3793a833d910952bc91e9ce36bd36642 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20402058 13596535 |
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