دورية أكاديمية

Baculovirus AcMNPV induces type I interferons and NK/NKT cells-mediated protection against foot-and-mouth disease virus in mice.

التفاصيل البيبلوغرافية
العنوان: Baculovirus AcMNPV induces type I interferons and NK/NKT cells-mediated protection against foot-and-mouth disease virus in mice.
المؤلفون: Molina, Guido Nicolás1 (AUTHOR), Cacciabue, Marco1 (AUTHOR), Gismondi, María Inés1 (AUTHOR), Taboga, Oscar1 (AUTHOR), Molinari, Paula1 (AUTHOR) molinari.maria@inta.gob.ar
المصدر: Antiviral Research. Aug2020, Vol. 180, pN.PAG-N.PAG. 1p.
مصطلحات موضوعية: *TYPE I interferons, *FOOT & mouth disease, *VIRUS diseases, *MOUSE diseases, *KILLER cells, *INTERFERON receptors
مستخلص: Foot-and-mouth disease is a viral illness that affects cloven-hoofed animals causing serious economic losses. Inactivated vaccines against its causative agent, foot-and-mouth disease virus (FMDV), require approximately seven days to induce protection. Therefore, antiviral strategies are needed to provide earlier protection and to stop the spread of this highly contagious virus during outbreak situations. In this way, our group has previously demonstrated that the baculovirus (BV) Autographa californica multiple nucleopolyhedrovirus (AcMNPV), an insect virus with immunostimulant effects, induces a nonspecific antiviral status that protects C57BL/6 mice against a lethal challenge with FMDV A/Arg/01 at 3 hours or 3 days post inoculation. In this work, we studied the immunological mechanisms involved in this protection. Firstly, we compared the protection elicited by AcMNPV in wild type mice and in knock-out mice lacking the subunit IFNAR1 of the receptor for type I interferons (IFNs). Our results showed that type I IFNs are key to prevent the death of the animals after the FMDV challenge. On the other hand, we evaluated the role of NK and NKT cells by depleting these cell subsets with anti-NK1.1 monoclonal antibody. These cells proved to be necessary for the induction of IFN-γ by AcMNPV and to prevent the onset of a severe disease after the FMDV challenge. We propose BV as a novel tool for the development of antiviral strategies because of the high levels of IFNs induced and the NK/NKT cells-mediated immune response elicited. Image 1 • Baculovirus promotes early and nonspecific protection against FMDV in mice. • This antiviral status is mainly mediated by the type I IFN system. • NK cells are necessary for the induction of type II IFNs. • NK cells are needed to prevent the onset of the disease. [ABSTRACT FROM AUTHOR]
قاعدة البيانات: Academic Search Index
الوصف
تدمد:01663542
DOI:10.1016/j.antiviral.2020.104850