التفاصيل البيبلوغرافية
| العنوان: |
Does Dietary Iodine Regulate Oxidative Stress and Adiponectin Levels in Human Breast Milk? |
| المؤلفون: |
Gutiérrez-Repiso, Carolina1, Velasco, Inés2, Garcia-Escobar, Eva1,3, Garcia-Serrano, Sara1,3, Rodríguez-Pacheco, Francisca1,3, Linares, Francisca1,3, Ruiz de Adana, Maria Soledad1,3, Rubio-Martin, Elehazara1,3, Garrido-Sanchez, Lourdes4,5, Cobos-Bravo, Juan Francisco6, Priego-Puga, Tatiana6, Rojo-Martinez, Gemma1,3, Soriguer, Federico1,3,5, García-Fuentes, Eduardo3,5 |
| المصدر: |
Antioxidants & Redox Signaling. 2/10/2014, Vol. 20 Issue 5, p847-853. 7p. |
| مصطلحات موضوعية: |
*OXIDATIVE stress, *ADIPONECTIN, *BREAST milk, *OBESITY, *GLUTATHIONE peroxidase |
| مستخلص: |
Little is known about the association between iodine and human milk composition. In this study, we investigated the association between iodine and different markers of oxidative stress and obesity-related hormones in human breast milk. This work is composed of two cross-sectional studies (in lactating women and in the general population), one prospective and one in vitro. In the cross-sectional study in lactating women, the breast milk iodine correlated negatively with superoxide dismutase (SOD), catalase, and glutathione peroxidase (GSH-Px) activities, and with adiponectin levels. An in vitro culture of human adipocytes with 1 μ M potassium iodide (KI, dose similar to the human breast milk iodine concentration) produced a significant decrease in adiponectin, GSH-Px, SOD1, and SOD2 mRNA expression. However, after 2 months of treatment with KI in the prospective study, a positive correlation was found between 24-h urinary iodine and serum adiponectin. Our observations lead to the hypothesis that iodine may be a factor directly involved in the regulation of oxidative stress and adiponectin levels in human breast milk. Antioxid. Redox Signal. 20, 847-853. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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