Environmental Factors-Induced Oxidative Stress: Hormonal and Molecular Pathway Disruptions in Hypogonadism and Erectile Dysfunction
| العنوان: | Environmental Factors-Induced Oxidative Stress: Hormonal and Molecular Pathway Disruptions in Hypogonadism and Erectile Dysfunction |
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| المؤلفون: | Petr Slama, Peter Massanyi, Niraj Kumar Jha, Monika Nath, Kavindra Kumar Kesari, Arun Paul Choudhury, Anandan Das, Shubhadeep Roychoudhury, Janne Ruokolainen, Saptaparna Chakraborty |
| المصدر: | Antioxidants Antioxidants, Vol 10, Iss 837, p 837 (2021) |
| بيانات النشر: | MDPI, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Infertility, Physiology, erectile dysfunction, Clinical Biochemistry, air pollution, Environmental pollution, RM1-950, Review, 010501 environmental sciences, Bioinformatics, medicine.disease_cause, 01 natural sciences, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, medicine, Endocrine system, hypogonadism, heavy metals, endocrine-disrupting chemicals, Molecular Biology, pesticide, 0105 earth and related environmental sciences, 030219 obstetrics & reproductive medicine, business.industry, Heavy metals, Testosterone (patch), Cell Biology, medicine.disease, radiation, Erectile dysfunction, testosterone, Therapeutics. Pharmacology, business, infertility, Oxidative stress, Hormone |
| الوصف: | Hypogonadism is an endocrine disorder characterized by inadequate serum testosterone production by the Leydig cells of the testis. It is triggered by alterations in the hypothalamic–pituitary–gonadal axis. Erectile dysfunction (ED) is another common disorder in men that involves an alteration in erectile response–organic, relational, or psychological. The incidence of hypogonadism and ED is common in men aged over 40 years. Hypogonadism (including late-onset hypogonadism) and ED may be linked to several environmental factors-induced oxidative stresses. The factors mainly include exposure to pesticides, radiation, air pollution, heavy metals and other endocrine-disrupting chemicals. These environmental risk factors may induce oxidative stress and lead to hormonal dysfunctions. To better understand the subject, the study used many keywords, including “hypogonadism”, “late-onset hypogonadism”, “testosterone”, “erectile dysfunction”, “reactive oxygen species”, “oxidative stress”, and “environmental pollution” in major online databases, such as SCOPUS and PUBMED to extract relevant scientific information. Based on these parameters, this review summarizes a comprehensive insight into the important environmental issues that may have a direct or indirect association with hypogonadism and ED in men. The study concludes that environmental factors-induced oxidative stress may cause infertility in men. The hypothesis and outcomes were reviewed critically, and the mechanistic approaches are applied through oxidant-sensitive pathways. This study also provides reccomendations on future therapeutic interventions and protective measures against such adverse environmental factors-induced hypogonadism and ED. |
| اللغة: | English |
| تدمد: | 2076-3921 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbd74c9ec2ed13724615ceb4087fc7c0Test http://europepmc.org/articles/PMC8225220Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....bbd74c9ec2ed13724615ceb4087fc7c0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20763921 |
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