دورية أكاديمية
Increasing incidence and antimicrobial resistance in Escherichia coli bloodstream infections: a multinational population-based cohort study
| العنوان: | Increasing incidence and antimicrobial resistance in Escherichia coli bloodstream infections: a multinational population-based cohort study |
|---|---|
| المؤلفون: | MacKinnon, Melissa C, McEwen, Scott A, Pearl, David L, Lyytikäinen, Outi, Jacobsson, Gunnar, Collignon, Peter, Gregson, Daniel B, Valiquette, Louis, Laupland, Kevin B |
| المصدر: | Antimicrobial Resistance and Infection Control |
| بيانات النشر: | BioMed Central Ltd. |
| سنة النشر: | 2021 |
| المجموعة: | Queensland University of Technology: QUT ePrints |
| مصطلحات موضوعية: | Antimicrobial resistance, Bacteremia, Bloodstream infection, Escherichia coli, Incidence rate, Population-based, Third-generation cephalosporins |
| الوصف: | Background: Escherichia coli is an important pathogen in humans and is the most common cause of bacterial bloodstream infections (BSIs). The objectives of our study were to determine factors associated with E. coli BSI incidence rate and third-generation cephalosporin resistance in a multinational population-based cohort. Methods: We included all incident E. coli BSIs (2014–2018) from national (Finland) and regional (Australia [Canberra], Sweden [Skaraborg], and Canada [Calgary, Sherbrooke, and western interior]) surveillance. Incidence rates were directly age and sex standardized to the European Union 28-country 2018 population. Multivariable negative binomial and logistic regression models estimated factors significantly associated with E. coli BSI incidence rate and third-generation cephalosporin resistance, respectively. The explanatory variables considered for inclusion in both models were year (2014–2018), region (six areas), age (< 70-years-old and ≥ 70-years-old), and sex (female and male). Results: We identified 31,889 E. coli BSIs from 40.7 million person-years of surveillance. Overall and third-generation cephalosporin-resistant standardized rates were 87.1 and 6.6 cases/100,000 person-years, respectively, and increased 14.0% and 40.1% over the five-year study. Overall, 7.8% (2483/31889) of E. coli BSIs were third-generation cephalosporin-resistant. Calgary, Canberra, Sherbrooke, and western interior had significantly lower E. coli BSI rates compared to Finland. The significant association between age and E. coli BSI rate varied with sex. Calgary, Canberra, and western interior had significantly greater odds of third-generation cephalosporin-resistant E. coli BSIs compared to Finland. Compared to 2014, the odds of third-generation cephalosporin-resistant E. coli BSIs were significantly increased in 2016, 2017, and 2018. The significant association between age and the odds of having a third-generation cephalosporin-resistant E. coli BSI varied with sex. Conclusions: Increases in overall and ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | application/pdf |
| اللغة: | unknown |
| العلاقة: | https://eprints.qut.edu.au/226226/1/101405537.pdfTest; MacKinnon, Melissa C, McEwen, Scott A, Pearl, David L, Lyytikäinen, Outi, Jacobsson, Gunnar, Collignon, Peter, Gregson, Daniel B, Valiquette, Louis, & Laupland, Kevin B (2021) Increasing incidence and antimicrobial resistance in Escherichia coli bloodstream infections: a multinational population-based cohort study. Antimicrobial Resistance and Infection Control, 10(1), Article number: 131.; https://eprints.qut.edu.au/226226Test/; Centre for Healthcare Transformation; Faculty of Health; School of Clinical Sciences |
| الإتاحة: | https://doi.org/10.1186/s13756-021-00999-4Test https://eprints.qut.edu.au/226226Test/ |
| حقوق: | free_to_read ; http://creativecommons.org/licenses/by/4.0Test/ ; 2021 The Author(s) ; This work is covered by copyright. Unless the document is being made available under a Creative Commons Licence, you must assume that re-use is limited to personal use and that permission from the copyright owner must be obtained for all other uses. If the document is available under a Creative Commons License (or other specified license) then refer to the Licence for details of permitted re-use. It is a condition of access that users recognise and abide by the legal requirements associated with these rights. If you believe that this work infringes copyright please provide details by email to qut.copyright@qut.edu.au |
| رقم الانضمام: | edsbas.DF207CAF |
| قاعدة البيانات: | BASE |
| الوصف غير متاح. |