Baseline In Vitro Activities of the Antimalarials Pyronaridine and Methylene Blue against Plasmodium falciparum Isolates from Kenya
| العنوان: | Baseline In Vitro Activities of the Antimalarials Pyronaridine and Methylene Blue against Plasmodium falciparum Isolates from Kenya |
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| المؤلفون: | Lewa Pole, Eric O Ohuma, Alexis Nzila, Lynette Isabella Ochola, Steven M. Kiara, John Okombo, Leah Mwai |
| المصدر: | Antimicrobial Agents and Chemotherapy. 56:1105-1107 |
| بيانات النشر: | American Society for Microbiology, 2012. |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Plasmodium falciparum, Protozoan Proteins, Biology, Antimalarials, chemistry.chemical_compound, Parasitic Sensitivity Tests, In vivo, parasitic diseases, Animals, Humans, Pharmacology (medical), Malaria, Falciparum, Naphthyridines, Gene, Pharmacology, Pyronaridine, Polymorphism, Genetic, biology.organism_classification, Kenya, Virology, In vitro, Methylene Blue, Infectious Diseases, chemistry, Susceptibility, Malaria falciparum, Methylene blue |
| الوصف: | We have analyzed the in vitro activities of pyronaridine and methylene blue against 59 Plasmodium falciparum isolates from Kenya in association with polymorphisms in Pfcrt (codon 76), Pfmdr1 (codon 86), and Pfnhe (full sequence). The median inhibitory concentrations that kill 50% of parasites were 13.5 and 3.3 nM for pyronaridine and methylene blue, respectively. Their activities were not associated with polymorphisms in these genes. The drugs' high in vitro activities indicate that they would be efficacious against Kenyan isolates in vivo . |
| تدمد: | 1098-6596 0066-4804 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c1251b53fe57f4c7c8ebb6f46ce7b9d3Test https://doi.org/10.1128/aac.05454-11Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c1251b53fe57f4c7c8ebb6f46ce7b9d3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10986596 00664804 |
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