التفاصيل البيبلوغرافية
العنوان:
Sultam thiourea inhibition of West Nile virus
المؤلفون:
James D. Brien , Janko Nikolich-Zugich , Amelia Still , Tenzin Choesang Dhenub , Mohammad I. Sabri , Eric Barklis , Alec J. Hirsch , Ayna Alfadhli , Isabel Scholz
المصدر:
Antimicrobial agents and chemotherapy . 51(7)
سنة النشر:
2007
مصطلحات موضوعية:
animal diseases , viruses , Drug Evaluation, Preclinical , Virus Replication , Antiviral Agents , Virus , Flaviviridae , chemistry.chemical_compound , Inhibitory Concentration 50 , Structure-Activity Relationship , Chlorocebus aethiops , Structure–activity relationship , Animals , Pharmacology (medical) , Replicon , Vero Cells , Pharmacology , biology , Dose-Response Relationship, Drug , Molecular Structure , Thiourea , virus diseases , biology.organism_classification , Virology , nervous system diseases , Flavivirus , Infectious Diseases , Viral replication , chemistry , Vero cell , RNA, Viral , West Nile virus
الوصف:
We have identified sultam thioureas as novel inhibitors of West Nile virus (WNV) replication. One such compound inhibited WNV, with a 50% effective concentration of 0.7 μM, and reduced reporter expression from cells that harbored a WNV-based replicon. Our results demonstrate that sultam thioureas can block a postentry, preassembly step of WNV replication.
تدمد:
0066-4804
الوصول الحر:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea1ec127ec36cccf5ec30edb423afa6eTest https://pubmed.ncbi.nlm.nih.gov/17452483Test
حقوق:
OPEN
رقم الانضمام:
edsair.doi.dedup.....ea1ec127ec36cccf5ec30edb423afa6e
قاعدة البيانات:
OpenAIRE
