Single nucleotide polymorphisms and clinical outcome in patients with biliary tract carcinoma treated with epirubicin, cisplatin and capecitabine
| العنوان: | Single nucleotide polymorphisms and clinical outcome in patients with biliary tract carcinoma treated with epirubicin, cisplatin and capecitabine |
|---|---|
| المؤلفون: | Pacetti, P., Elisa Giovannetti, Mambrini, A., Nannizzi, S., Orlandi, M., Tartarini, R., Del Freo, A., Del Tacca, M., Danesi, R., Cantore, M. |
| المساهمون: | Medical oncology laboratory, CCA - Innovative therapy |
| المصدر: | Anticancer Research, 29(5), 1835-1840. International Institute of Anticancer Research Scopus-Elsevier Pacetti, P, Giovannetti, E, Mambrini, A, Nannizzi, S, Orlandi, M, Tartarini, R, Del Freo, A, Del Tacca, M, Danesi, R & Cantore, M 2009, ' Single Nucleotide Polymorphisms and Clinical Outcome in Patients with Biliary Tract Carcinoma Treated with Epirubicin, Cisplatin and Capecitabine ', Anticancer Research, vol. 29, no. 5, pp. 1835-1840 . |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Adult, Aged, 80 and over, Male, Middle Aged, Endonucleases, Deoxycytidine, Polymorphism, Single Nucleotide, Biliary tract carcinoma, DNA-Binding Proteins, Biliary Tract Neoplasms, Treatment Outcome, X-ray Repair Cross Complementing Protein 1, Antineoplastic Combined Chemotherapy Protocols, capecitabine, cisplatin, Humans, Female, Fluorouracil, Cisplatin, Capecitabine, Aged, Epirubicin, Xeroderma Pigmentosum Group D Protein |
| الوصف: | Biliary tract carcinoma (BTC) is a rare highly malignant neoplasia. Polymorphisms at the xeroderma pigmentosum group D (XPD), excision repair cross-complementing group-1 (ERCC1) and X-ray repair cross complementing group 1 (XRCC1) genes were evaluated and correlated with clinical outcome.Thirty-three patients with BTC were treated with intravenous or intra-arterial cisplatin and epirubicin and oral capecitabine. The ERCC1-C118T, XPD-Asp312Asn, XPD-Lys751Gln and XRCC1-Arg399Gln polymorphisms were studied.A partial response (PR) occurred in 6 patients. The median progression-free (PFS) and overall survival (OS) were 4.8 and 18.9 months, respectively. No significant correlations were observed between response, PFS and OS in patients grouped according to all the studied polymorphisms. The analysis of survival starting from diagnosis resulted in a significant association of the XRCC1-Arg399Arg variant with a shorter survival.A role of the XRCC1-Arg399Gln polymorphism as a possible prognostic factor in patients affected by BTC is suggested. |
| تدمد: | 0250-7005 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::2d33525115f40fac54ece06c418ad968Test https://pubmed.ncbi.nlm.nih.gov/19443413Test |
| حقوق: | RESTRICTED |
| رقم الانضمام: | edsair.pmid.dedup....2d33525115f40fac54ece06c418ad968 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 02507005 |
|---|