دورية أكاديمية
Concurrent NRAS-BRAF variants in metastatic colorectal cancer: a Tunisian case report.
| العنوان: | Concurrent NRAS-BRAF variants in metastatic colorectal cancer: a Tunisian case report. |
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| المؤلفون: | Douik, Hayet, Sahraoui, Ghada, Jemaà, Mohamed, Doghri, Raoudha, Charfi, Lamia, Mrad, Karima |
| المصدر: | Anticancer Drugs ; ISSN:1473-5741 ; Volume:35 ; Issue:5 |
| بيانات النشر: | Wolters Kluwer |
| سنة النشر: | 2024 |
| المجموعة: | PubMed Central (PMC) |
| الوصف: | Target therapy for metastatic colorectal cancer needs the determination of KRAS, NRAS, and BRAF mutation status to identify patients resistant to anti-EGFR treatment. RAS genes (KRAS/NRAS) are mutated in 40-60% of metastatic colorectal cancer and BRAF in 5-10%. The presence of a double mutation in RAS and BRAF is rare. Therefore, RAS and BRAF mutations were considered exclusive. Herein, we describe a novel concomitant NRAS/BRAF mutation identified in a series of 865 colorectal cancer patients. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.1097/CAD.0000000000001586Test; https://pubmed.ncbi.nlm.nih.gov/38451831Test |
| DOI: | 10.1097/CAD.0000000000001586 |
| الإتاحة: | https://doi.org/10.1097/CAD.0000000000001586Test https://pubmed.ncbi.nlm.nih.gov/38451831Test |
| حقوق: | Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved. |
| رقم الانضمام: | edsbas.4585BC6E |
| قاعدة البيانات: | BASE |
| DOI: | 10.1097/CAD.0000000000001586 |
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