The Ends Dictate the Means: Promoter Switching in Herpesvirus Gene Expression
| العنوان: | The Ends Dictate the Means: Promoter Switching in Herpesvirus Gene Expression |
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| المؤلفون: | Nathaniel J. Moorman, Andrew E. Hale |
| المصدر: | Annual Review of Virology. 8:201-218 |
| بيانات النشر: | Annual Reviews, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Gene Expression Regulation, Viral, Genetics, Genes, Viral, business.industry, viruses, Viral Genes, Gene Expression, Biology, Viral gene, Cell Line, Virus Latency, Text mining, Lytic cycle, Transcription (biology), Virology, Herpesvirus 8, Human, Gene expression, Latency (engineering), Promoter Regions, Genetic, business, Herpesviridae |
| الوصف: | Herpesvirus gene expression is dynamic and complex, with distinct complements of viral genes expressed at specific times in different infection contexts. These complex patterns of viral gene expression arise in part from the integration of multiple cellular and viral signals that affect the transcription of viral genes. The use of alternative promoters provides an increased level of control, allowing different promoters to direct the transcription of the same gene in response to distinct temporal and contextual cues. While once considered rare, herpesvirus alternative promoter usage was recently found to be far more pervasive and impactful than previously thought. Here we review several examples of promoter switching in herpesviruses and discuss the functional consequences on the transcriptional and post-transcriptional regulation of viral gene expression. |
| تدمد: | 2327-0578 2327-056X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34e0b7834a8bd8cb1bc85ed8a6f39d7fTest https://doi.org/10.1146/annurev-virology-091919-072841Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....34e0b7834a8bd8cb1bc85ed8a6f39d7f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23270578 2327056X |
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