Mechanisms of Cell Protection by Heme Oxygenase-1
| العنوان: | Mechanisms of Cell Protection by Heme Oxygenase-1 |
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| المؤلفون: | Raffaella Gozzelino, Viktória Jeney, Miguel P. Soares |
| المصدر: | Annual Review of Pharmacology and Toxicology. 50:323-354 |
| بيانات النشر: | Annual Reviews, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Oxygenase, Programmed cell death, Apoptosis, Heme, Toxicology, Gene Expression Regulation, Enzymologic, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Animals, Humans, 030304 developmental biology, Inflammation, Pharmacology, Carbon Monoxide, 0303 health sciences, Biliverdin, Tumor Necrosis Factor-alpha, Biliverdine, Cytoprotection, 3. Good health, Heme oxygenase, chemistry, Biochemistry, 030220 oncology & carcinogenesis, Protoporphyrin, Heme Oxygenase-1 |
| الوصف: | Heme oxygenases (HO) catabolize free heme, that is, iron (Fe) protoporphyrin (IX), into equimolar amounts of Fe2+, carbon monoxide (CO), and biliverdin. The stress-responsive HO-1 isoenzyme affords protection against programmed cell death. The mechanism underlying this cytoprotective effect relies on the ability of HO-1 to catabolize free heme and prevent it from sensitizing cells to undergo programmed cell death. This cytoprotective effect inhibits the pathogenesis of a variety of immune-mediated inflammatory diseases. |
| تدمد: | 1545-4304 0362-1642 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d308f7ea34bc7dd57d32a62e9c31419Test https://doi.org/10.1146/annurev.pharmtox.010909.105600Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....2d308f7ea34bc7dd57d32a62e9c31419 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15454304 03621642 |
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