Protein Phosphatases of Pathogenic Bacteria: Role in Physiology and Virulence
| العنوان: | Protein Phosphatases of Pathogenic Bacteria: Role in Physiology and Virulence |
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| المؤلفون: | Vipin Chandra Kalia, Gunjan Arora, Yogendra Singh, Andaleeb Sajid, Anshika Singhal |
| المصدر: | Annual Review of Microbiology. 69:527-547 |
| بيانات النشر: | Annual Reviews, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Bacteria, Virulence, biology, Phosphatase, Pathogenic bacteria, Bacterial Physiological Phenomena, medicine.disease_cause, biology.organism_classification, Microbiology, Cofactor, Cell biology, Biochemistry, Phosphoprotein Phosphatases, medicine, biology.protein, Receptor, Cellular compartment |
| الوصف: | The role of protein phosphatases in pathogenic bacteria has been studied extensively over the last two decades. Ser/Thr and Tyr phosphatases are associated with growth and virulence of many bacteria. These phosphatases control kinase-mediated functions and return the proteins to their unmodified state. Biochemical, structural, and functional studies, in addition to extensive genetic characterization, have highlighted the importance of phosphatases in bacteria. However, questions remain regarding the mechanisms driving localization of secretory phosphatases to cellular compartments, identification of receptor phosphatase sensory signals, and a possible role of cofactors and ligands in their functions. This review focuses on the role of Ser/Thr- and Tyr-specific phosphatases present in pathogenic bacteria, with an emphasis on the regulation of basic cellular processes and virulence. Furthermore, we highlight their clinical importance and analyze the development of drugs targeting protein phosphatases. |
| تدمد: | 1545-3251 0066-4227 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7a47aca7a5f024cb8aaf1bf0509224aTest https://doi.org/10.1146/annurev-micro-020415-111342Test |
| رقم الانضمام: | edsair.doi.dedup.....a7a47aca7a5f024cb8aaf1bf0509224a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15453251 00664227 |
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