التفاصيل البيبلوغرافية
| العنوان: |
Mediation, Modulation, and Consequences of Membrane-Cytoskeleton Interactions. |
| المؤلفون: |
Doherty, Gary J.1 doherty@mrc-lmb.cam.ac.uk, McMahon, Harvey T.1 hmm@mrc-lmb.cam.ac.uk |
| المصدر: |
Annual Review of Biophysics. 2008, Vol. 37, p65-95. 31p. 1 Diagram. |
| مصطلحات موضوعية: |
*PROTEIN-protein interactions, *CELL membrane formation, *CYTOSKELETON formation, *CELL adhesion -- Molecular aspects, *ETIOLOGY of diseases, *CELL migration |
| مستخلص: |
Elements of the cytoskeleton interact intimately and communicate bidirectionally with cellular membranes. Such interactions are critical for a host of cellular processes. Here we focus on the many types of interactions that exist between the cytoskeleton and the plasma membrane to illustrate why these cellular components can never truly be studied in isolation in vivo. We discuss how membrane-cytoskeleton interactions are mediated and modulated, and how many proteins involved in these interactions are disrupted in human disease. We then highlight key molecular and physical variables that must be considered in order to mechanistically dissect events associated with changes in plasma membrane morphology. These considerations are integrated into the context of cell migration, filopodia formation, and clathrin-mediated endocytosis to show how a holistic view of the plasma rnembrane-cytoskeleton interface can allow for the appropriate interpretation of experimental findings and provide novel mechanistic insight into these important cellular events. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
