دورية أكاديمية
Short Term Outcomes in Indian Patients with High Risk Prostate Cancer after Laparoscopic Radical Prostatectomy- Data from a Single Institute
| العنوان: | Short Term Outcomes in Indian Patients with High Risk Prostate Cancer after Laparoscopic Radical Prostatectomy- Data from a Single Institute |
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| المؤلفون: | Prashant Patel, Shrenik J Shah, Arpan Choudhary |
| المصدر: | Annals of Urologic Oncology (2020) |
| بيانات النشر: | Asian Medical Press Ltd.(H.K.) |
| سنة النشر: | 2020 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | high risk prostate cancer, laparoscopic radical prostatectomy, biochemical recurrence, Medicine |
| الوصف: | Background Management of high risk prostate cancer (HRPC) is in evolving stage. Effectiveness of the various treatment strategies is being explored. We examined the short term efficacy of laparoscopic radical prostatectomy (LRP) in treatment of patients with HRPC. Methods Retrospective observational study had 140 HRPC patients of Indian origin, based on D’Amico classification system. Baseline workup was completed. Perioperative parameters and pathological findings were recorded. Multivariate analysis was performed to find predictive factors of pathological stage and PSM. 5 year biochemical recurrence free survival (BCRFS), cancer specific survival (CSS) and overall survival (OS) were calculated. Results Mean age and PSA were 67.24±7.37 years and 23.29 ng/ml respectively. Three fourth of patients had a biopsy GS ≥8. 53.6% of patients were of clinical stage (CS) ≤T2; while 46.4% were of stage ≥T3. Conversion to open surgery rate was 15%. Mean operative time was 210 minutes; blood loss 230 ml; hospital stay 3 days; catheterization time 14 days; grade II or more complication rate 22.1%; LN positivity 20.0%; PSM rate 25.7%; upstaging 35.7%; down-staging 14.3%; pT2 31.4%; pT3a 26.4%; pT3b 42.2%. GS and CS were predictive of pathological stage and PSM respectively. 89.3% of cases were continent postoperatively. 5 year BCRFS, CSS and OS were 68.3%, 89.2% and 78.7% respectively. Conclusions LRP is feasible and effective initial treatment for HRPC. Perioperative morbidity is acceptable. Accurate staging helps in better planning of the adjuvant therapy. Good short term survival can be achieved with multimodal therapy. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2617-7765 2617-7773 |
| العلاقة: | http://auo.asmepress.com/articles/new-35-771.htmlTest; https://doaj.org/toc/2617-7765Test; https://doaj.org/toc/2617-7773Test; https://doaj.org/article/8115c17520ae46ad9dc8c6ae0c3b34eeTest |
| DOI: | 10.32948/auo.2020.09.29 |
| الإتاحة: | https://doi.org/10.32948/auo.2020.09.29Test https://doaj.org/article/8115c17520ae46ad9dc8c6ae0c3b34eeTest |
| رقم الانضمام: | edsbas.5B2DAAE4 |
| قاعدة البيانات: | BASE |
| تدمد: | 26177765 26177773 |
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| DOI: | 10.32948/auo.2020.09.29 |