Henoch-Schönlein purpura in children: an epidemiological study among Dutch paediatricians on incidence and diagnostic criteria
| العنوان: | Henoch-Schönlein purpura in children: an epidemiological study among Dutch paediatricians on incidence and diagnostic criteria |
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| المؤلفون: | Gracita Ramnath, Jean-Claude Davin, Rob Rodrigues Pereira, Joost A. Aalberse, Koerd Dolman |
| المساهمون: | AII - Amsterdam institute for Infection and Immunity, Paediatric Infectious Diseases / Rheumatology / Immunology, Paediatric Nephrology, TNO Kwaliteit van Leven |
| المصدر: | Annals of the rheumatic diseases, 66(12), 1648-1650. BMJ Publishing Group Annals of the Rheumatic Diseases, 12, 66, 1648-1650 |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Male, Pediatrics, Henoch-Schonlein purpura, kidney disease, Biopsy, epidemiological data, anaphylactoid purpura, Kidney, immunology, Epidemiology, dipeptidyl carboxypeptidase inhibitor, Immunology and Allergy, antibiotic agent, Child, Netherlands, Skin, Purpura, Schoenlein-Henoch, abdominal disease, medicine.diagnostic_test, Incidence (epidemiology), adult, Incidence, Complement C3, biological marker, Extended Report, arthritis, Health, diagnostic test, Antibodies, Antinuclear, epidemiology, Biological Markers, Female, antinuclear antibody, Vasculitis, medicine.medical_specialty, IgA Vasculitis, Thrombotic thrombocytopenic purpura, Sensitivity and Specificity, General Biochemistry, Genetics and Molecular Biology, Antibodies, Antineutrophil Cytoplasmic, complement component C3, Rheumatology, Jeugd en Gezondheid, meprednisone, blood, medicine, Humans, controlled study, neutrophil cytoplasmic antibody, skin biopsy, business.industry, medicine.disease, infant, major clinical study, human tissue, Surgery, Immunoglobulin A, Epidemiologic Studies, El Niño, adolescent, Skin biopsy, prednisone, business, Biomarkers, Kidney disease |
| الوصف: | Background: The aim of the present study on the occurrence of Henoch-Schonlein Purpura ( HSP) in Dutch children is to give some insight into the epidemiology of HSP in the Netherlands, to record the diagnostic criteria used by Dutch paediatricians and to evaluate the accuracy of the latter using the presence of IgA in the skin when biopsies are available. Methods: Each month in 2004, all Dutch paediatricians received an electronic card asking them to mention new diagnosed HSP. Paediatricians reporting one or more new patients with HSP were sent a list of questions concerning various parameters. Results: 232 patients from 0 to 18 years of age ( 6.1/10(5)) were reported as having contracted HSP in 2004. 29% presented renal symptoms. In accordance with the classification criteria of the American College of Rheumatology, 80% of paediatricians consider that isolated purpura ( without haematological abnormalities) is sufficient to allow the diagnosis of HSP in children. From the 17 skin biopsies performed, only 9 ( 53%) presented IgA deposits. The follow-up duration, considered as necessary, was longer in case of renal symptoms at presentation. However, 45% of patients without renal symptoms would be followed for more than 1 year. Conclusion: Considering the recent ( 2006) EULAR/PReS endorsed consensus criteria for the classification of childhood vasculitides, HSP should have been diagnosed in only 160 of the 179 patients of our study. The use of isolated non-thrombocytopenic purpura as the only criterion to diagnose HSP in children might therefore lead to over diagnosis and unnecessary follow-up |
| اللغة: | English |
| تدمد: | 0003-4967 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::258b95e1b6fd5978db3b734ed0c9ccecTest https://doi.org/10.1136/ard.2006.069187Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....258b95e1b6fd5978db3b734ed0c9ccec |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00034967 |
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