Antinuclear autoantibodies: discordance among four different assays
| العنوان: | Antinuclear autoantibodies: discordance among four different assays |
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| المؤلفون: | Juan-Manuel Anaya, Cilia Rojas, Yovana Pacheco, Yeny Acosta-Ampudia, Carolina Ramírez-Santana, Diana M. Monsalve |
| المصدر: | Annals of the Rheumatic Diseases. 79:e6-e6 |
| بيانات النشر: | BMJ, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 030203 arthritis & rheumatology, 0301 basic medicine, medicine.medical_specialty, medicine.diagnostic_test, Anti-nuclear antibody, business.industry, Concordance, Disease duration, Immunology, Autoantibody, Disease, Gastroenterology, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Rheumatology, Internal medicine, Immunoassay, medicine, Immunology and Allergy, Line immunoassay, skin and connective tissue diseases, business, Anti-SSA/Ro autoantibodies |
| الوصف: | Detection of antinuclear antibodies (ANAs) is of paramount importance for diagnosis and assessment of autoimmune diseases (ADs), but may vary depending on the method used. Therefore, we aimed to compare three different line immunoassays (LIAs) for ANAs testing in order to simultaneously evaluate their concordance with the results obtained by a well known and widely used ELISA. Sera from women with established systemic lupus erythematosus (SLE, n=62) and Sjogren’s syndrome (SS, n=28) were examined. Patients with SLE had an average age of 48.7 years (IQR 36.8–57.0) with a disease duration of 14.8 years (IQR 9.0–18.0). Patients with SS had an average age of 62.1 years (IQR 55.5–71.0) with a duration of disease of 13.1 years (IQR 8.3–17). Table 1 shows the results from the two-by-two comparison for the four techniques. Different levels of agreement were observed among the assays. In general, they were deficient. The analysis showed only one ‘strong’ level of agreement between ELISA and IMTEC-ANA-LIA Maxx for anti-Ro measurement. Out of 39 comparisons, 14 did … |
| تدمد: | 1468-2060 0003-4967 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::b6d50312f84c182f39071fe9618b76ceTest https://doi.org/10.1136/annrheumdis-2018-214693Test |
| رقم الانضمام: | edsair.doi...........b6d50312f84c182f39071fe9618b76ce |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14682060 00034967 |
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