التفاصيل البيبلوغرافية
| العنوان: |
Childhood socioeconomic factors and perinatal characteristics influence development of rheumatoid arthritis in adulthood. |
| المؤلفون: |
Parks, Christine G., D'Aloisio, Aimee A., DeRoo, Lisa A., Huiber, Kirstin, Rider, Lisa G., Miller, Frederick W., Sandler, Dale P. |
| المصدر: |
Annals of the Rheumatic Diseases; Mar2013, Vol. 72 Issue 3, p350-356, 7p, 4 Charts |
| مستخلص: |
Background Rheumatoid arthritis (RA) has been associated with lower socioeconomic status (SES), but the reasons for this are not known. Objective To examine childhood SES measures, SES trajectory and other perinatal factors in relation to RA. Methods The sample included 50 884 women, aged 35-74 (84% non-Hispanic white) enrolled 2004-9 in a US national cohort study. In baseline questionnaires, cases (N=424, 0.8%) reported RA diagnosis after age 16, ever use of disease-modifying antirheumatic drugs or steroids for RA and =6 weeks bilateral joint swelling. Childhood SES measures are presented as OR and 95% CI adjusted for age and race/ethnicity. Analyses of perinatal factors also adjusted for childhood SES, and joint effects of childhood and adult SES and smoking exposures were evaluated. Results Patients with RA reported lower childhood household education (<12 years vs college degree; OR=1.7; 95% CI 1.1 to 2.5), food insecurity (OR=1.5, 95% CI 1.1 to 2.0) and young maternal age (<20 vs 20-34 years; OR=1.7, 95% CI 1.2 to 2.5), with a trend (p<0.0001) for increasing number of adverse factors (OR=3.0; 95% CI 1.3 to 7.0; 4 vs 0 factors) compared with non-cases. High birth weight (>4000 g) and preconception paternal smoking were independently associated with RA. Together, lower childhood SES and adult education (
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| قاعدة البيانات: |
Complementary Index |
