Heterogeneous Expression of Neuroendocrine Marker Proteins in Human Undifferentiated Carcinoma of the Colon and Rectum
| العنوان: | Heterogeneous Expression of Neuroendocrine Marker Proteins in Human Undifferentiated Carcinoma of the Colon and Rectum |
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| المؤلفون: | Julia Schönfelder, Gudrun Ahnert-Hilger, Martin Zeitz, Hans-Dieter Foss, Harald Stein, Patricia Grabowski, Hans Scherübl, Gerd Berger |
| المصدر: | Annals of the New York Academy of Sciences. 1014:270-274 |
| بيانات النشر: | Wiley, 2004. |
| سنة النشر: | 2004 |
| مصطلحات موضوعية: | Adult, Male, Pathology, medicine.medical_specialty, Synaptosomal-Associated Protein 25, Colorectal cancer, Cell, Synaptophysin, Vesicular Transport Proteins, Syntaxin 1, Rectum, Alpha (ethology), Nerve Tissue Proteins, Neuroendocrine differentiation, General Biochemistry, Genetics and Molecular Biology, R-SNARE Proteins, History and Philosophy of Science, Biomarkers, Tumor, medicine, Humans, Survival rate, Aged, Aged, 80 and over, biology, General Neuroscience, Membrane Proteins, Chromogranin A, Cell Differentiation, Middle Aged, Prognosis, medicine.disease, Immunohistochemistry, Soluble N-Ethylmaleimide-Sensitive Factor Attachment Proteins, Neuroendocrine Tumors, medicine.anatomical_structure, Antigens, Surface, biology.protein, Female, Carrier Proteins, Colorectal Neoplasms, SNARE Proteins |
| الوصف: | The expression of neuroendocrine marker proteins in undifferentiated colorectal cancers has not yet been studied in great detail. Therefore, the survival of 20 patients with small cell undifferentiated colorectal cancers treated at our institution between 1982 and 1997 (0.8% of all operated colorectal carcinomas) was correlated with the extent of neuroendocrine differentiation. Chromogranin A, synaptophysin, syntaxin1, VAMP2, SNAP25, and alpha/beta-SNAP were used as neuroendocrine markers. Based on the degree of immunoreactivity for these marker proteins, tumors were divided into group 0 (2% cells stained positive for neuroendocrine markers) and group 1 (2% cells stained positive). Patients were followed up for at least 5 years or until death. Nine of twenty (45%) undifferentiated colorectal tumors expressed neuroendocrine markers (group 1). Only one patient of this group survived 2 years (11%), whereas the 2-year survival rate was 45.4% in group 0. Nine of eleven patients of group 0 were diagnosed in UICC stage I-III, whereas eight of nine tumors with expression of neuroendocrine markers were diagnosed in UICC stage IV (P = 0.002). Our results show that neuroendocrine differentiation is often seen in small cell undifferentiated colorectal cancer. It correlates with a more aggressive course of the disease. |
| تدمد: | 1749-6632 0077-8923 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f3713cdb6479c484453c02542cd8e7Test https://doi.org/10.1196/annals.1294.030Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....a4f3713cdb6479c484453c02542cd8e7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17496632 00778923 |
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