Cigarette smoking and risk of Hodgkin lymphoma and its subtypes: a pooled analysis from the International Lymphoma Epidemiology Consortium (InterLymph)
| العنوان: | Cigarette smoking and risk of Hodgkin lymphoma and its subtypes: a pooled analysis from the International Lymphoma Epidemiology Consortium (InterLymph) |
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| المؤلفون: | John R. McLaughlin, Shelia Hoar Zahm, Mads Kamper-Jørgensen, Henrik Hjalgrim, John J. Spinelli, Tongzhang Zheng, C. La Vecchia, N Becker, Punam Pahwa, Sally L. Glaser, Paolo Boffetta, Ellen T. Chang, Lenka Foretová, Pierluigi Cocco, Klaus Rostgaard, Wendy Cozen, James A. Dosman, Lucia Miligi, Alexandra Nieters, Diego Serraino, Paolo Vineis, Alain Monnereau, Paul Brennan, Karin E. Smedby, Anthony Staines, Marc Maynadié, Eleanor Kane, Martine Vornanen, S. Sanjose |
| المساهمون: | Kamper-Jørgensen, M., Rostgaard, K., Glaser, S.L., Zahm, S.H., Cozen, W., Smedby, K.E., Sanjosé, S., Chang, E.T., Zheng, T., La Vecchia, C., Serraino, D., Monnereau, A., Kane, E.V., Miligi, L., Vineis, P., Spinelli, J.J., McLaughlin, J.R., Pahwa, P., Dosman, J.A., Vornanen, M., Foretova, L., Maynadie, M., Staines, A., Becker, N., Nieters, A., Brennan, P., Boffetta, P., Cocco, P., Hjalgrim, H., International Prevention Research Institute (IPRI), The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai [New York] (MSSM) |
| المصدر: | Annals of Oncology Annals of Oncology, Elsevier, 2013, 24 (9), pp.2245-55. ⟨10.1093/annonc/mdt218⟩ |
| بيانات النشر: | Elsevier BV, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Adult, Male, Risk, Oncology, Epstein-Barr Virus Infections, Herpesvirus 4, Human, medicine.medical_specialty, Adolescent, Reviews, cigarette smoking, Young Adult, Nodular sclerosis, Risk Factors, Internal medicine, Epidemiology, case–control, medicine, Humans, Epstein–Barr viru, individual patient data meta-analysis, Young adult, Aged, Aged, 80 and over, business.industry, Smoking, Confounding, Case-control study, Tobacco Use Disorder, Hematology, Odds ratio, Middle Aged, medicine.disease, Hodgkin Disease, Lymphoma, Social Class, Case-Control Studies, Immunology, Etiology, Female, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, epidemiology, business, Hodgkin lymphoma |
| الوصف: | Kamper-Jorgensen, M Rostgaard, K Glaser, S L Zahm, S H Cozen, W Smedby, K E Sanjose, S Chang, E T Zheng, T La Vecchia, C Serraino, D Monnereau, A Kane, E V Miligi, L Vineis, P Spinelli, J J McLaughlin, J R Pahwa, P Dosman, J A Vornanen, M Foretova, L Maynadie, M Staines, A Becker, N Nieters, A Brennan, P Boffetta, P Cocco, P Hjalgrim, H eng 5 ROI CA69269/CA/NCI NIH HHS/ Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't England 2013/06/22 06:00 Ann Oncol. 2013 Sep;24(9):2245-55. doi: 10.1093/annonc/mdt218. Epub 2013 Jun 19.; International audience; BACKGROUND: The etiology of Hodgkin lymphoma (HL) remains incompletely characterized. Studies of the association between smoking and HL have yielded ambiguous results, possibly due to differences between HL subtypes. PATIENTS AND METHODS: Through the InterLymph Consortium, 12 case-control studies regarding cigarette smoking and HL were identified. Pooled analyses on the association between smoking and HL stratified by tumor histology and Epstein-Barr virus (EBV) status were conducted using random effects models adjusted for confounders. Analyses included 3335 HL cases and 14 278 controls. RESULTS: Overall, 54.5% of cases and 57.4% of controls were ever cigarette smokers. Compared with never smokers, ever smokers had an odds ratio (OR) of HL of 1.10 [95% confidence interval (CI) 1.01-1.21]. This increased risk reflected associations with mixed cellularity cHL (OR = 1.60, 95% CI 1.29-1.99) and EBV-positive cHL (OR = 1.81, 95% CI 1.27-2.56) among current smokers, whereas risk of nodular sclerosis (OR = 1.09, 95% CI 0.90-1.32) and EBV-negative HL (OR = 1.02, 95% CI 0.72-1.44) was not increased. CONCLUSION: These results support the notion of etiologic heterogeneity between HL subtypes, highlighting the need for HL stratification in future studies. Even if not relevant to all subtypes, our study emphasizes that cigarette smoking should be added to the few modifiable HL risk factors identified. |
| وصف الملف: | ELETTRONICO |
| تدمد: | 0923-7534 1569-8041 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c867f6c9dbe138b595e0d0abb8dc36afTest https://doi.org/10.1093/annonc/mdt218Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....c867f6c9dbe138b595e0d0abb8dc36af |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09237534 15698041 |
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