دورية
In vivo detection of microglial activation in frontotemporal dementia
| العنوان: | In vivo detection of microglial activation in frontotemporal dementia |
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| المؤلفون: | Cagnin, Annachiara, Rossor, Martin, Sampson, Elizabeth L., MacKinnon, Toby, Banati, Richard B. |
| المصدر: | Annals of Neurology; December 2004, Vol. 56 Issue: 6 p894-897, 4p |
| مستخلص: | Using positron emission tomography and [11C](R)‐PK11195, a marker of “peripheral benzodiazepine sites” that is upregulated on activated microglia during progressive tissue pathology, we show increased binding of [11C](R)‐PK11195 in frontotemporal lobar degeneration in the typically affected frontotemporal brain regions. This implies the presence of an active glial response reflecting progressive neuronal degeneration. It also suggests that increased [11C](R)‐PK11195 binding, previously demonstrated for Alzheimer's disease, may occur independently from increased amyloid plaque formation, given that it is not a characteristic feature of frontotemporal lobar degeneration. Ann Neurol 2004;56:894–897 |
| قاعدة البيانات: | Supplemental Index |
| تدمد: | 03645134 15318249 |
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| DOI: | 10.1002/ana.20332 |