التفاصيل البيبلوغرافية
| العنوان: |
Parafoveal Change and Dopamine Loss in the Retina with Parkinson's Disease. |
| المؤلفون: |
Lee, Jee‐Young1 (AUTHOR) wieber04@snu.ac.kr, Ahn, Jeeyun2 (AUTHOR), Shin, Joo Young2 (AUTHOR), Jeon, Beomseok3 (AUTHOR) |
| المصدر: |
Annals of Neurology. Feb2021, Vol. 89 Issue 2, p421-422. 2p. |
| مصطلحات موضوعية: |
*PARKINSON'S disease, *RETINA, *DOPAMINE, *RAPID eye movement sleep, *RETINAL injuries |
| مستخلص: |
Dear Editor, We read with great interest the article by Ortuño-Lizarán and colleagues,1 in which the authors provide a color-coded density map of dopaminergic cells in the macular region showing more pronounced reduction at the inferotemporal compared with the superonasal region in Parkinson's disease (PD) patients (Fig1 A). The thinning was more prominent in de novo PD than in prodromal subjects, but both showed significant thinning compared with healthy controls (see Fig1 B), suggesting earlier onset of retinal dopamine cell loss, preceding the clinical appearance of parkinsonian motor symptoms. Prominent loss of retinal dopaminergic cells in the inferotemporal macula might be related to the different distribution and density of P- and M-type ganglion cells, because P-cells are presumed to be more affected in PD.4 Also, although an autopsy study showed aberrant ganglion cell morphology and ganglion cell loss with alpha-synuclein-positive inclusions in PD retina,5 retinal dopamine loss seemed to be related to neither ganglion cell loss nor Lewy-type pathology. [Extracted from the article] |
| قاعدة البيانات: |
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